抑郁与慢性疼痛相关的神经生物学共同机制研究进展

被引:19
作者
刘义 [1 ]
高静芳 [2 ]
机构
[1] 浙江中医药大学
[2] 浙江中医药大学一附院精神卫生科
关键词
抑郁障碍; 慢性疼痛; 病理机制;
D O I
暂无
中图分类号
R749.4 [情感性精神病];
学科分类号
摘要
临床上,抑郁障碍可以伴随慢性疼痛,慢性疼痛也可以引发抑郁障碍,两者常常相互伴随、相互影响,本文试图阐述抑郁障碍和慢性疼痛在神经生物学机制上可能存在的共同机制,目前研究多集中在中枢神经系统和神经内分泌调节失调两方面,通过阐述原理、引用证据,从而揭示两者在病因学上的关系。
引用
收藏
页码:155 / 157
页数:3
相关论文
共 20 条
[1]  
Gender differences in depression and chronic pain conditions in a national epidemiologic survey. SE Munce,DE Stewart. Psychosomatics . 2007
[2]  
Periaqueductal gray neurons project to spinally projecting GABAergic neurons in the rostral ventromedial medulla. Morgan MM,Whittier KL,Hegarty DM et al. Pain . 2008
[3]  
Treatment of fibromyalgia syndromes with antidepressants: a meta-analysis. W. Hauser,K. Bernardy,N. Uceyler. The Journal of The American Medical Association . 2009
[4]  
Pain modulation: expectation, opioid analgesia and virtual pain. Fields,H. Progress in Brain Research . 2000
[5]  
HPA axis reactivity in chronic pelvic pain:association with depression. Wingenfeld K,Hellhammer DH,Schmidt I,et al. Journal of Psychosomatic Obstetrics and Gynecology . 2009
[6]  
Association of major depressive disorder with altered functional brain re-sponse during anticipation and processing of heat pain. Strigo I A,,Simmons AN,Matthews S C,et al. Archives of General Psychiatry . 2008
[7]  
Neurobio-logical mechanis ms in major depressive disorder. aan het ROT M,,MATHEWS J,CHARNEY D S. Canadian Medical Association Journal . 2009
[8]  
Chronic pain, chronic stress, and depression: coincidence or consequence?. Blackburn-Munro,G,Blackburn-Munro,RE. Journal of Neuroendocrinology . 2001
[9]   Neurobiological mechanisms in major depressive disorder [J].
aan het Rot, Marije ;
Mathew, Sanjay J. ;
Charney, Dennis S. .
CANADIAN MEDICAL ASSOCIATION JOURNAL, 2009, 180 (03) :305-313
[10]  
Does hypothalamic–pituitary–adrenal axis hypofunction in chronic fatigue syndrome reflect a ‘crash’ in the stress system?[J] . Boudewijn Van Houdenhove,Filip Van Den Eede,Patrick Luyten. &nbspMedical Hypotheses . 2009 (6)