MS-551抗缺血性室性心律失常的实验研究

被引：1

作者：

孟玲

李小鹰

单兆亮

宋立功

机构：

[1] 解放军总医院老年心内科!北京,解放军总医院老年心内科!北京,解放军总医院心内科!北京,解放军总医院老年心内科!北京

来源：

中国应用生理学杂志 | 2000年 / 03期

关键词：

MS551; Ⅲ类抗心律失常药物; 有效不应期; 室性心律失常;

D O I：

10.13459/j.cnki.cjap.2000.03.020

中图分类号：

R541.7 [心律失常];

学科分类号：

1002 ; 100201 ;

摘要：

目的 :研究新型Ⅲ类抗心律失常药物MS 5 5 1,即 1,3二甲基 6 [2 (N 2羟乙基 3 4硝苯丙氨基 )乙氨基 ] 2 ,4(1H ,3H) 盐酸嘧啶二酮 (MS) ,对麻醉犬心肌的电生理作用和对缺血性室性心律失常的防治效果。方法 :测定用药(MS首剂 0 5mg/kg于 5min内静推 ,维持量 0 5mg/kg静滴 30min)前后正常犬心肌房室不应期 ,并观察MS[首剂 0 3mg/kg于 5min内静推 ,维持量 0 5mg/ (kg·min)静滴 30min]对程序刺激诱发梗塞后犬缺血性室性心律失常的预防作用。结果 :MS显著延长麻醉犬心房和心室有效不应期 (ms) (12 8.6± 6 7vs 15 5 7± 4 8和 12 2 9± 7 5vs 143 6± 5 0 ,P均 <0 .0 1) ,以及QTc间期 (10 4± 0 4vs 12 0± 0 6 )。 7只梗塞后犬中有 5只经程序刺激诱发出室颤 ,用MS后无 1例再发室颤。未见致心律失常作用。结论 :MS可考虑作为防治缺血性室性心律失常的选择用药之一 ,对预防室颤具有一定意义。

引用

页码：51 / 53

页数：3

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