乙型肝炎肝衰竭发生机制中的三重打击

被引:26
作者
叶一农
高志良
机构
[1] 中山大学附属第三医院传染科
关键词
肝炎,乙型; 肝功能衰竭; 缺血; 缺氧; 再灌注损伤; 内毒素血症; 免疫损伤;
D O I
暂无
中图分类号
R512.62 []; R575.3 [肝功能衰竭];
学科分类号
100401 ; 1002 ; 100201 ;
摘要
肝衰竭发生和发展的机制十分复杂,叶一农等翔实地阐述了乙型肝炎肝衰竭发生和发展过程中的免疫损伤、缺血缺氧性损伤和内毒素血症损伤的三重打击现象,并结合临床将肝衰竭的发生和发展过程分为4个时相:上升前期、上升期、平台期、恢复期,针对不同时相的损伤特征提出相应的治疗策略
引用
收藏
页码:638 / 640 +5
相关论文
共 6 条
[1]   Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B [J].
Zhang, Zheng ;
Zhang, Ji-Yuan ;
Wherry, E. John ;
Jin, Bo ;
Xu, Bin ;
Zou, Zheng-Sheng ;
Zhang, Shu-Ye ;
Li, Bao-Sen ;
Wang, Hui-Feng ;
Wu, Hao ;
Lau, George K. K. ;
Fu, Yang-Xin ;
Wang, Fu-Sheng .
GASTROENTEROLOGY, 2008, 134 (07) :1938-1949
[2]   Cellular and molecular mechanisms of liver injury [J].
Malhi, Harmeet ;
Gores, Gregory J. .
GASTROENTEROLOGY, 2008, 134 (06) :1641-1654
[3]   Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure [J].
Zhang, Zheng ;
Zou, Zheng-Sheng ;
Fu, Jun-Liang ;
Cai, Lun ;
Jin, Lei ;
Liu, Yong-Jun ;
Wang, Fu-Sheng .
JOURNAL OF HEPATOLOGY, 2008, 49 (03) :396-406
[4]   Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury [J].
Langdale, Lorrie A. ;
Hoagland, Vicki ;
Benz, Whitney ;
Riehle, Kimberly J. ;
Campbell, Jean S. ;
Liggitt, Denny H. ;
Fausto, Nelson .
JOURNAL OF HEPATOLOGY, 2008, 49 (02) :198-206
[5]  
The significance of autoantibodies and immunoglobulins in acute liver failure: A cohort study[J] . William Bernal,Yun Ma,Heather M. Smith,Bernard Portmann,Julia Wendon,Diego Vergani.Journal of Hepatology . 2007 (5)
[6]   Increased serum and hepatic tissue levels of interleukin-18 in patients with fulminant hepatic failure [J].
Shinoda, Masahiro ;
Wakabayashi, Go ;
Shimazu, Motohide ;
Saito, Hidetsugu ;
Hoshino, Ken ;
Tanabe, Minoru ;
Morikawa, Yasuhide ;
Endo, Shigeatsu ;
Ishii, Hiromasa ;
Kitajima, Masaki .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2006, 21 (11) :1731-1736