沙库巴曲缬沙坦在心衰治疗中的应用:从临床试验到真实世界

被引：65

作者：

陈文文

刘燕琳

李振山

尹玲

耿涛

党和勤

机构：

[1] 泰山医学院附属医院药剂科

来源：

中国医院药学杂志 | 2018年 / 38卷 / 21期

关键词：

心衰; 血管紧张素受体脑啡肽酶抑制剂; 沙库巴曲缬沙坦;

D O I：

10.13286/j.cnki.chinhosppharmacyj.2018.21.20

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

100201 [内科学];

摘要：

传统心衰药物治疗方案在一定程度上可改善患者心衰症状,但无法有效降低患者死亡率及因心衰住院率,因此开发新型心衰治疗药物迫在眉睫。2015年,具有双重作用机制的血管紧张素受体脑啡肽酶抑制剂(angiotensin receptor neprilysin enzyme inhibitor,ARNI)沙库巴曲缬沙坦被美国食品药品监督管理局(the Food and Drug Administration,FDA)批准上市,为心衰患者的治疗带来了新的希望。本文综述了沙库巴曲缬沙坦的药学性质,更新了相关临床试验结果,并介绍其在真实世界中的应用效果,以期为临床心衰药物治疗提供参考。

引用

页码：2286 / 2290

页数：5

共 14 条

[1]

血管紧张素受体-脑啡肽酶抑制剂LCZ696 [J].

匡泽民 ;

王瑛 ;

王佳洁 ;

余振球 .

中国新药杂志, 2016, 25 (21) :2415-2420

[2]

Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial [J].

Seferovic, Jelena P. ;

Claggett, Brian ;

Seidelmann, Sara B. ;

Seely, Ellen W. ;

Packer, Milton ;

Zile, Michael R. ;

Rouleau, Jean L. ;

Swedberg, Karl ;

Lefkowitz, Martin ;

Shi, Victor C. ;

Desai, Akshay S. ;

McMurray, John J. V. ;

Solomon, Scott D. .

LANCET DIABETES & ENDOCRINOLOGY, 2017, 5 (05) :333-340

[3]

Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure [J].

Zile, Michael R. ;

Claggett, Brian L. ;

Prescott, Margaret F. ;

McMurray, John J. V. ;

Packer, Milton ;

Rouleau, Jean L. ;

Swedberg, Karl ;

Desai, Akshay S. ;

Gong, Jianjian ;

Shi, Victor C. ;

Solomon, Scott D. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (22) :2425-2436

[4]

Geographic variations in the PARADIGM-HF heart failure trial [J].

Kristensen, Soren Lund ;

Martinez, Felipe ;

Jhund, Pardeep S. ;

Arango, Juan Luis ;

Belohlavek, Jan ;

Boytsov, Sergey ;

Cabrera, Walter ;

Gomez, Efrain ;

Hagege, Albert A. ;

Huang, Jun ;

Kiatchoosakun, Songsak ;

Kim, Kee-Sik ;

Mendoza, Ivan ;

Senni, Michele ;

Squire, Iain B. ;

Vinereanu, Dragos ;

Wong, Raymond Ching-Chiew ;

Gong, Jianjian ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Solomon, Scott D. ;

Swedberg, Karl ;

Zile, Michael R. ;

Packer, Milton ;

McMurray, John J. V. .

EUROPEAN HEART JOURNAL, 2016, 37 (41) :3167-+

[5]

Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) According to Background Therapy [J].

Okumura, Naoki ;

Jhund, Pardeep S. ;

Gong, Jianjian ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Swedberg, Karl ;

Zile, Michael R. ;

Solomon, Scott D. ;

Packer, Milton ;

McMurray, John J. V. .

CIRCULATION-HEART FAILURE, 2016, 9 (09)

[6]

LCZ 696 (Valsartan/Sacubitril) – A Possible New Treatment for Hypertension and Heart Failure.[J].Mathilde Borring Andersen;Ulf Simonsen;Markus Wehland;Jessica Pietsch;Daniela Grimm.Basic Clin Pharmacol Toxicol.2016, 1

[7]

Effects of age and sex on the pharmacokinetics of LCZ696, an angiotensin receptor neprilysin inhibitor [J].

Gan, Lu ;

Langenickel, Thomas ;

Petruck, Jesika ;

Kode, Kiran ;

Rajman, Iris ;

Chandra, Priya ;

Zhou, Wei ;

Rebello, Sam ;

Sunkara, Gangadhar .

JOURNAL OF CLINICAL PHARMACOLOGY, 2016, 56 (01) :78-86

[8]

Kristensen, Soren L. ;

Preiss, David ;

Jhund, Pardeep S. ;

Squire, Iain ;

Cardoso, Jose Silva ;

Merkely, Bela ;

Martinez, Felipe ;

Starling, Randall C. ;

Desai, Akshay S. ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Solomon, Scott D. ;

Swedberg, Karl ;

Zile, Michael R. ;

McMurray, John J. V. ;

Packer, Milton .

CIRCULATION-HEART FAILURE, 2016, 9 (01)

[9]

Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF [J].

Jhund, Pardeep S. ;

Fu, Michael ;

Bayram, Edmundo ;

Chen, Chen-Huan ;

Negrusz-Kawecka, Marta ;

Rosenthal, Arvo ;

Desai, Akshay S. ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Solomon, Scott D. ;

Swedberg, Karl ;

Zile, Michael R. ;

McMurray, John J. V. ;

Packer, Milton .

EUROPEAN HEART JOURNAL, 2015, 36 (38) :2576-2584

[10]

Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure [J].

Packer, Milton ;

McMurray, John J. V. ;

Desai, Akshay S. ;

Gong, Jianjian ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Solomon, Scott D. ;

Swedberg, Karl ;

Zile, Michael ;

Andersen, Karl ;

Arango, Juan Luis ;

Arnold, J. Malcolm ;

Belohlavek, Jan ;

Bohm, Michael ;

Boytsov, Sergey ;

Burgess, Lesley J. ;

Cabrera, Walter ;

Calvo, Carlos ;

Chen, Chen-Huan ;

Dukat, Andrej ;

Duarte, Yan Carlos ;

Erglis, Andrejs ;

Fu, Michael ;

Gomez, Efrain ;

Gonzalez-Medina, Angel ;

Hagege, Albert A. ;

Huang, Jun ;

Katova, Tzvetana ;

Kiatchoosakun, Songsak ;

Kim, Kee-Sik ;

Kozan, Oemer ;

Llamas, Edmundo Bayram ;

Martinez, Felipe ;

Merkely, Bela ;

Mendoza, Ivan ;

Mosterd, Arend ;

Negrusz-Kawecka, Marta ;

Peuhkurinen, Keijo ;

Ramires, Felix J. A. ;

Refsgaard, Jens ;

Rosenthal, Arvo ;

Senni, Michele ;

Sibulo, Antonio S., Jr. ;

Silva-Cardoso, Jose ;

Squire, Iain B. ;

Starling, Randall C. ;

Teerlink, John R. ;

Vanhaecke, Johan .

CIRCULATION, 2015, 131 (01) :54-61

← 1 2 →