雷公藤甲素药代动力学研究进展

被引：10

作者：

邰婷 ^{[1
]}

江振洲 ^{[2
,3
]}

黄鑫 ^{[2
,3
]}

吉金子 ^{[1
]}

张陆勇 ^{[1
,3
]}

机构：

[1] 中国药科大学江苏省新药筛选中心

[2] 中国药科大学药物质量与安全预警教育部重点实验室

[3] 江苏省药效研究与评价服务中心

来源：

药学与临床研究 | 2012年 / 20卷 / 03期

关键词：

雷公藤甲素; 药代动力学; 毒性; 衍生物; 制剂;

D O I：

10.13664/j.cnki.pcr.2012.03.009

中图分类号：

R285 [中药药理学];

学科分类号：

100806 [中药药理学];

摘要：

雷公藤甲素(TP)作为雷公藤的主要活性成分,具有抗炎、免疫抑制、抗生育、抗囊肿和抗肿瘤等作用,但其治疗窗窄,对消化系统、泌尿生殖系统和血液系统等有较大的毒副作用,因此临床开发研究受到了一定限制。本文主要针对TP药代动力学的研究进行整理和归纳,并概述了基于改善TP体内药动学特性所研发的新型TP衍生物和相关制剂,以期为TP的新药开发研究提供助益。

引用

页码：229 / 235

页数：7

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