轻型颅脑损伤患者脑网络小世界属性的功能磁共振成像研究

被引：5

作者：

徐灿鑫 ^{[1
]}

王博成 ^{[2
]}

陈二涛 ^{[1
]}

赵志杰 ^{[1
]}

冯东福 ^{[1
]}

机构：

[1] 上海交通大学医学院附属第九人民医院神经外科

[2] 上海交通大学医学院附属第九人民医院医学影像科

来源：

中华行为医学与脑科学杂志 | 2019年 / 28卷 / 07期

关键词：

颅脑创伤; 脑网络; 小世界; 功能磁共振成像;

D O I：

暂无

中图分类号：

R651.15 []; R445.2 [核磁共振成像];

学科分类号：

100231 [临床病理学];

摘要：

目的研究轻型颅脑损伤(mild traumatic brain injury, mTBI)对功能脑网络参数的影响, 分析mTBI患者脑网络小世界属性的变化。方法收集上海交通大学医学院附属第九人民医院神经外科轻型颅脑损伤患者10例及年龄、性别相互匹配的健康对照组13例, 采集所有受试者的静息态功能磁共振图像, 构建功能网络, 分析脑网络属性。结果在所选择的稀疏度范围下颅脑损伤组与健康对照组均具有小世界属性。颅脑损伤患者的全局效率与健康对照组相比显著降低[(0.174±0.141)、(0.184±0.062), t=2.417, P=0.025], 最短路径长度较健康对照组显著增加[(0.797±0.930)、(0.734±0.488), t=-2.083, P=0.048]。结论轻型颅脑损伤患者功能脑网络具有小世界属性, 患者功能脑网络的参数发生改变。

引用

共 15 条

[1]

Mild Traumatic Brain Injury: Longitudinal Study of Cognition, Functional Status, and Post-Traumatic Symptoms [J].

Dikmen, Sureyya ;

Machamer, Joan ;

Temkin, Nancy .

JOURNAL OF NEUROTRAUMA, 2017, 34 (08) :1524-1530

[2]

Small world brain network characteristics during EEG Holter recording of a stroke event [J].

Vecchio, Fabrizio ;

Miraglia, Francesca ;

Romano, Angela ;

Bramanti, Placido ;

Rossini, Paolo Maria .

CLINICAL NEUROPHYSIOLOGY, 2017, 128 (01) :1-3

[3]

Systematic Review of Self-Reported Prognosis in Adults After Mild Traumatic Brain Injury: Results of the International Collaboration on Mild Traumatic Brain Injury Prognosis.[J].J. David Cassidy;Carol Cancelliere;Linda J. Carroll;Pierre Côté;Cesar A. Hincapié;Lena W. Holm;Jan Hartvigsen;James Donovan;Catharina Nygren-de Boussard;Vicki L. Kristman;Jörgen Borg.Archives of Physical Medicine and Rehabilitation.2014, 3S

[4]

Traumatic brain injury impairs small-world topology [J].

Pandit, Anand S. ;

Expert, Paul ;

Lambiotte, Renaud ;

Bonnelle, Valerie ;

Leech, Robert ;

Turkheimer, Federico E. ;

Sharp, David J. .

NEUROLOGY, 2013, 80 (20) :1826-1833

[5]

Graph analysis of functional brain networks for cognitive control of action in traumatic brain injury..[J].Caeyenberghs Karen;Leemans Alexander;Heitger Marcus H;Leunissen Inge;Dhollander Thijs;Sunaert Stefan;Dupont Patrick;Swinnen Stephan P.Brain : a journal of neurology.2012, Pt 4

[6]

Human brain networks in health and disease [J].

Bassett, Danielle S. ;

Bullmore, Edward T. .

CURRENT OPINION IN NEUROLOGY, 2009, 22 (04) :340-347

[7]

Complex brain networks: graph theoretical analysis of structural and functional systems [J].

Bullmore, Edward T. ;

Sporns, Olaf .

NATURE REVIEWS NEUROSCIENCE, 2009, 10 (03) :186-198

[8]

Network analysis of intrinsic functional brain connectivity in Alzheimer's disease [J].

Supekar, Kaustubh ;

Menon, Vinod ;

Rubin, Daniel ;

Musen, Mark ;

Greicius, Michael D. .

PLOS COMPUTATIONAL BIOLOGY, 2008, 4 (06)

[9]

Disrupted small-world networks in schizophrenia..[J].Liu Yong;Liang Meng;Zhou Yuan;He Yong;Hao Yihui;Song Ming;Yu Chunshui;Liu Haihong;Liu Zhening;Jiang Tianzi.Brain : a journal of neurology.2008, Pt 4

[10]

Disruption of large-scale brain systems in advanced aging [J].

Andrews-Hanna, Jessica R. ;

Snyder, Abraham Z. ;

Vincent, Justin L. ;

Lustig, Cindy ;

Head, Denise ;

Raichle, Marcus E. ;

Buckner, Randy L. .

NEURON, 2007, 56 (05) :924-935

← 1 2 →