雌激素与免疫在绝经后骨质疏松发病机理中的研究进展

被引：12

作者：

郑倩华

秦尔奇

赵中亭

孙玮

李瑛

机构：

[1] 成都中医药大学针灸推拿学院

来源：

中国医学创新 | 2014年 / 11卷 / 13期

关键词：

绝经后骨质疏松; 免疫系统; 雌激素; 淋巴细胞; 细胞因子;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

骨质疏松症(osteoporosis,OPS)是一种以单位体积内骨量低于正常为特征的骨骼疾患,是骨质有机成分生成不足、继发性钙盐减少及骨组织微细结构破坏为主要表现的一类疾病。绝经后骨质疏松症(postmenopausal osteoporosis,PMO)属于原发性OPS,其与绝经后雌激素的减少有着密不可分的关系。近年来,许多研究表明骨骼疾病如类风湿性关节炎、骨转移、牙周炎和OPS等的发生与免疫系统有着密切的关系,从而新生了骨免疫学这一交叉学科。PMO的发生不仅与雌激素能影响破骨细胞和成骨细胞的功能有关,还与其能影响绝经后免疫系统及多种细胞因子等功能有关。本文就PMO与绝经后免疫系统之间的关系展开简要论述。

引用

页码：147 / 150

页数：4

共 8 条

[1]

Historically significant events in the discovery of RANK/RANKL/OPG [J].

Martin, T. John .

WORLD JOURNAL OF ORTHOPEDICS, 2013, 4 (04) :186-197

[2]

T cells: Critical bone regulators in health and disease [J].

Pacifici, Roberto .

BONE, 2010, 47 (03) :461-471

[3]

Contribution of Serum Inflammatory Markers to Changes in Bone Mineral Content and Density in Postmenopausal Women: A 1-Year Investigation [J].

Gertz, E. R. ;

Silverman, N. E. ;

Wise, K. S. ;

Hanson, K. B. ;

Alekel, D. L. ;

Stewart, J. W. ;

Perry, C. D. ;

Bhupathiraju, S. N. ;

Kohut, M. L. ;

Van Loan, M. D. .

JOURNAL OF CLINICAL DENSITOMETRY, 2010, 13 (03) :277-282

[4]

Effect of IL‐1β; PGE<sub>2</sub>; and TGF‐β1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts.[J].SusanaJurado;NataliaGarcia‐Giralt;AdolfoDíez‐Pérez;PedroEsbrit;GuyYoskovitz;LídiaAgueda;RoserUrreizti;LluísPérez‐Edo;GuillemSaló;LeonardoMellibovsky;SusanaBalcells;DanielGrinberg;XavierNogués.J. Cell. Biochem..2010, 2

[5]

Immune changes in post-menopausal osteoporosis: the Immunos study [J].

Breuil, V. ;

Ticchioni, M. ;

Testa, J. ;

Roux, C. H. ;

Ferrari, P. ;

Breittmayer, J. P. ;

Albert-Sabonnadiere, C. ;

Durant, J. ;

De Perreti, F. ;

Bernard, A. ;

Euller-Ziegler, L. ;

Carle, G. F. .

OSTEOPOROSIS INTERNATIONAL, 2010, 21 (05) :805-814

[6]

Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: A key mechanism in osteoporosis [J].

D'Amelio, Patrizia ;

Grimaldi, Anastasia ;

Di Bella, Stefania ;

Brianza, Stefano Z. M. ;

Cristofaro, Maria Angela ;

Tamone, Cristina ;

Giribaldi, Giuliana ;

Ulliers, Daniela ;

Pescarmona, Gian P. ;

Isaia, Giancarlo .

BONE, 2008, 43 (01) :92-100

[7]

The effect of 17β-estradiol on production of cytokines in cultures of peripheral blood [J].

Rogers, A ;

Eastell, R .

BONE, 2001, 29 (01) :30-34

[8]

Up-regulation of TNF-producing T cells in the bone marrow: A key mechanism by which estrogen deficiency induces bone loss in vivo..Cristiana Roggia;Yuhao Gao;Simone Cenci;M. Neale Weitzmann;Gianluca Toraldo;Giancarlo Isaia;Roberto Pacifi;.PNAS.2001, 98

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