肿瘤坏死因子对培养内皮细胞的损伤作用——循环内皮细胞形成机制初探

被引：20

作者：

杨映波

王正国

朱佩芳

机构：

[1] 第三军医大学第三附属医院野战外科研究所创伤急救科,第三军医大学第三附属医院野战外科研究所第四研究室,第三军医大学第三附属医院野战外科研究所第四研究室

来源：

中国循环杂志 | 1993年 / 06期

关键词：

肿瘤坏死因子; 人脐静脉内皮细胞; 循环内皮细胞; 纤溶酶原激活剂抑制物;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

本文以原代培养的人脐静脉内皮细胞(HUVEC)为材料,研究了肿瘤坏死因子(TNF)对HUVEC的损伤作用及循环内皮细胞(CEC)的形成机制。实验结果表明,TNF能造成HUVEC大片脱落,并出现了与CEC极为相似的形态。同时,TNF明显破坏了纤溶酶原激活剂抑制物活性。结果表明,TNF的直接细胞毒作用可致HUVEC转变成CEC的细胞形态,TNF浓度增加可能是病理情况下CEC增多的重要原因。

引用

页码：353 / 356+384 +384-385

页数：6

共 8 条

[1]

Endothelial lesion in hypertension. Hladovec J,Prerovsky I. Cor et Vasa . 1989

[2]

Circulating endothelial cells isolated together with platelet and the experimental modification of their counts in rats. Hladovec J,Rossman P. Thrombosis Research . 1973

[3]

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo. van Hinsbergh VWM,Kooistra T,van den Berg EA,et al. Blood . 1988

[4]

Circulating endothelial cells fail to induce cerebral infarction in rabbits. Iwata Y,Kuzuya F,Hayakawa M,et al. Stroke . 1986

[5]

Modulation of endothelial cell hemostatic properties by tumor necrosis factor. Nawroth PP,Stern DM. The Journal of Experimental Medicine . 1986

[6]

Tumor necrosis factor/cachetin increases permeability of endothelial cell monolayers by a mechanism involving regulatory G proteins. Brett J,Gerlach H,Nawroth P,et al. The Journal of Experimental Medicine . 1989

[7]

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. Stolpen AH,Guinan EA,Fiers W,et al. American Journal of Pathology . 1986

[8]

Circulating endothelial cells as a sign of vessel wall lesions. Hladovec J. Physiologia Bohemoslovaca . 1978

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