华法林给药剂量预测模型的建立与应用

被引:9
作者
庄文芳 [1 ]
吴婧 [1 ]
李莉 [2 ]
机构
[1] 上海市长宁区中心医院血液病实验室
[2] 上海交通大学附属第一人民医院检验科
关键词
剂量预测模型; 华法林; 单核苷酸多态性CYP2C9; VKORC1; CYP4F2;
D O I
暂无
中图分类号
R973.2 [];
学科分类号
摘要
<正>华法林是临床上广泛应用的抗凝剂,可用于治疗房颤、深静脉血栓、肺栓塞、瓣膜移植等[1],而且价格便宜。但是华法林个体药物代谢能力的差异很大,治疗安全范围狭窄,影响其药效的因素又很多,使得华法林个体剂量的变动性很大(0.5~60.0 mg/d),还会存在严重的潜在出血
引用
收藏
页码:1157 / 1161
页数:5
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