瑞舒伐他汀改善大量饮酒对急性心肌梗死大鼠血管新生的影响

被引:5
作者
屈福超
王爱红
孙永乐
王勇
苑海涛
张玉英
机构
[1] 山东大学附属省立医院心血管内科
关键词
大量饮酒; 心肌梗死; 血管新生; 瑞舒伐他汀;
D O I
暂无
中图分类号
R541.4 [冠状动脉(粥样)硬化性心脏病(冠心病)];
学科分类号
100201 [内科学];
摘要
目的探讨大量饮酒对急性心肌梗死后血管新生的影响以及瑞舒伐他汀的干预作用。方法取雄性SD大鼠24只,随机分成3组:空白对照组、大量饮酒组[50%食用乙醇,5 g/(kg·d)]和瑞舒伐他汀预处理组[瑞舒伐他汀20 mg/(kg·d)+大量饮酒组50%食用乙醇,5 g/(kg·d)]。喂养4周后制做心肌梗死模型,于术后第3天处死,采用免疫组织化学SP法检测梗死边缘区心肌内微血管密度(MVD),应用ELISA法测定心肌组织中血管内皮生长因子(VEGF)及内皮抑素的表达。结果与空白对照组相比,大量饮酒组MVD明显减少(P<0.01),VEGF表达无明显差异,内皮抑素表达明显增加(P<0.01);与大量饮酒组相比,瑞舒伐他汀预处理组MVD明显升高(P<0.01),VEGF和内皮抑素水平均无明显差异(P>0.05)。结论大量饮酒抑制心肌梗死大鼠缺血心肌的血管新生,可能与增加内皮抑素的表达有关;瑞舒伐他汀能够减轻大量饮酒对缺血心肌血管新生的抑制作用。
引用
收藏
页码:22 / 25
页数:4
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