磺胺类碳酸酐酶抑制剂研究进展

被引：46

作者：

宋春泽 ^{[1
]}

周成合 ^{[1
]}

袁勇 ^{[2
]}

机构：

[1] 西南大学化学化工学院

[2] 重庆医科大学药学院

来源：

中国新药杂志 | 2007年 / 18期

关键词：

磺胺; 碳酸酐酶抑制剂; 抗青光眼; 抗肿瘤;

D O I：

暂无

中图分类号：

R98 [各科药物];

学科分类号：

100705 [微生物与生化药学];

摘要：

碳酸酐酶抑制剂(CAIs)作为药物具有广泛的生物活性,如抗青光眼、利尿、抗肿瘤、抗癫痫、抗风湿、降血糖等。近几年,新一代抗青光眼磺胺类CAIs已经取得很大的研究成果,抗肿瘤磺胺类CAIs的研究也日益活跃,发展极为迅速。现综述磺胺类CAIs在抗青光眼和抗肿瘤领域的研究进展。

引用

页码：1438 / 1444

页数：7

共 14 条

[1]

用作抗青光眼药物的碳酸酐酶抑制剂 [J].

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药学进展, 2002, (04) :202-205

[2]

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Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I; II; and IX with a series of 1;3;4-thiadiazole- and 1;2;4-triazole-thiols[J] Gabriela Laura Almajan;Alessio Innocenti;Luca Puccetti;Gheorghe Manole;Stefania Barbuceanu;Ioana Saramet;Andrea Scozzafava;Claudiu T. Supuran Bioorganic & Medicinal Chemistry Letters 2005,

[7]

Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides[J] Silvia Pastorekova;Daniela Vullo;Angela Casini;Andrea Scozzafava;Jaromir Pastorek;Isao Nishimori;Claudiu T. Supuran Journal of Enzyme Inhibition and Medicinal Chemis 2005,

[8]

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[9]

Cyclodextrin Complexes of Sulfonamide Carbonic Anhydrase IOnhibitors As Long‐lasting Topically Acting Antiglaucoma Agents[J] Francesca Maestrelli;Paola Mura;Angela Casini;Francesco Mincione;Andrea Scozzafava;Claudiu T. Supuran Journal of Pharmaceutical Sciences 2002,

[10]

Carbonic Anhydrase Inhibitors With Strong Topical Antiglaucoma Properties Incorporating a 4-(2-amino-pyrimidin-4-yl-amino)-benzenesulfonamide Scaffold[J] Angela Casini;Francesco Mincione;Daniela Vullo;Luca Menabuoni;Andrea Scozzafava;Claudiu T. Supuran Journal of Enzyme Inhibition and Medicinal Chemis 2002,

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