干预趋化因子治疗缺血性脑损伤

被引：3

作者：

王君

李振东

机构：

[1] 中山大学附属第五医院

来源：

中华脑血管病杂志(电子版) | 2009年 / 3卷 / 02期

关键词：

趋化因子; 缺血性脑损伤; 拮抗剂; 基因; 神经干细胞;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

100204 [神经病学];

摘要：

大量研究证实趋化因子参与缺血性脑损伤的病理生理过程。它们或者促进炎症反应,加重脑损伤,或者诱导神经干细胞迁移,促进损伤修复。因此拮抗趋化因子及其受体的作用,敲除趋化因子及其受体基因,以及促进其对神经干细胞的靶向作用有可能治疗缺血性脑损伤。广谱趋化因子拮抗剂的开发,趋化因子基因和蛋白表达的调控都有希望的方法,需要加强探索。

引用

页码：84 / 88

页数：5

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