血管内皮生长因子检测在阿司匹林联合Capox方案治疗老年转移性结肠癌的临床意义

被引：3

作者：

左新年 ^{[1
]}

丁江华 ^{[2
]}

刘潮涌 ^{[3
]}

机构：

[1] 解放军第医院消化科

[2] 解放军第医院肿瘤科

[3] 解放军第医院检验科

来源：

中华临床医师杂志(电子版) | 2014年 / 8卷 / 03期

关键词：

血管内皮生长因子类; 卡培他滨; 奥沙利铂; 阿司匹林; 老年人; 结肠肿瘤; 肿瘤转移;

D O I：

暂无

中图分类号：

R735.3 [肠肿瘤];

学科分类号：

100112 [医学生物化学与分子生物学];

摘要：

目的分析转移性结肠癌(mCRC)中血管内皮生长因子(VEGF)与阿司匹林(ASA)联合化疗疗效的关系,探讨ASA在mCRC中的可能机制。方法 74例无出血倾向的mCRC患者随机分2组:33例Capox方案组病例单纯接受化疗[卡培他滨1 000 mg·(m2)-1·d-1,每日2次,第1～14天;奥沙利铂130 mg/m2,第1天。每3周为1周期];41例Capox联合ASA组接受化疗外,于化疗期及化疗间歇期均持续口服ASA 75 mg/d,同时口服奥美拉唑20 mg/d保护胃黏膜。每周期化疗前均抽取静脉血检测VEGF含量。结果 (1)Capox+ASA组DCR显著高于Capox组(92.7%vs.66.7%,P<0.05),但两组OR无差异(45.5%vs.63.4%,P>0.05);(2)两组病例中,获DCR疗效亚组VEGF含量均明显低于PD疗效亚组(594.1±32.6 vs.1 029.8±58.8,477.1±13.3 vs.1 003.4±50.9,P<0.05);在DCR疗效亚组,Capox+ASA组VEGF含量显著低于Capox组(P<0.05),但在PD疗效亚组Capox组与Capox+ASA组VEGF含量无显著性差异(P>0.05)。结论 ASA联合Capox治疗老年转移性结肠癌患者,提高了疾病控制率,ASA部分抗癌机制为抑制VEGF表达。

引用

页码：430 / 433

页数：4

共 10 条

[1]

Low-dose aspirin and survival in men with prostate cancer: a study using the UK Clinical Practice Research Datalink [J].

Cardwell, Chris R. ;

Flahavan, Evelyn M. ;

Hughes, Carmel M. ;

Coleman, Helen G. ;

O'Sullivan, Joe M. ;

Powe, Des G. ;

Murray, Liam J. .

CANCER CAUSES & CONTROL, 2014, 25 (01) :33-43

[2]

Aspirin reduces lung cancer metastasis to regional lymph nodes[J] Fumihiro Ogawa;Hideki Amano;Yoshiya Ito;Yoshio Matsui;Kanako Hosono;Hidero Kitasato;Yukitoshi Satoh;Masataka Majima Biomedicine & Pharmacotherapy 2014,

[3]

Aberrant; ectopic expression of VEGF and VEGF receptors 1 and 2 in malignant colonic epithelial cells. implications for these cells growth via an autocrine mechanism[J] Amrita Ahluwalia;Michael K. Jones;Sandor Szabo;Andrzej S. Tarnawski Biochemical and Biophysical Research Communications 2013,

[4]

High levels of serum VEGF and TIMP-1 are correlated with colon cancer liver metastasis and intrahepatic recurrence after liver resection [J].

Min, Byung Soh ;

Kim, Nam Kyu ;

Jeong, Hee Chul ;

Chung, Hyun Cheol .

ONCOLOGY LETTERS, 2012, 4 (01) :123-130

[5]

Long-Term Effects of Aspirin on Colorectal Cancer [J].

Brown, Carl J. ;

Gallinger, Steven ;

Church, James .

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2012, 214 (06) :1023-1026

[6]

Prognostic importance of VEGF-A haplotype combinations in a stage II colon cancer population [J].

Kjaer-Frifeldt, Sanne ;

Fredslund, Rikke ;

Lindebjerg, Jan ;

Hansen, Torben Froestrup ;

Spindler, Karen-Lise Garm ;

Jakobsen, Anders .

PHARMACOGENOMICS, 2012, 13 (07) :763-770

[7]

Economic comparison of capecitabine + oxaliplatin and 5-fluorouracil + oxaliplatin in the adjuvant treatment of colon cancer[J] Giorgio Lorenzo Colombo;Giorgio Colombo;Anna Rossi;Enrico Aitini Cancer Management and Research 2012, defa

[8]

Bevacizumab-induced serious side-effects: a review of the French pharmacovigilance database [J].

Taugourdeau-Raymond, Solene ;

Rouby, F. ;

Default, A. ;

Jean-Pastor, M. -J. .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 68 (07) :1103-1107

[9]

First United Kingdom Heart and Renal Protection (UK-HARP-I) study: Biochemical efficacy and safety of simvastatin and safety of low-dose aspirin in chronic kidney disease[J] Colin Baigent;Martin Landray;Craig Leaper;Paul Altmann;Jane Armitage;Alex Baxter;Hugh S. Cairns;Rory Collins;Robert N. Foley;Valeria Frighi;Karen Kourellias;Peter J. Ratcliffe;Mary Rogerson;John E. Scoble;Charles R.V. Tomson;David C. Wheeler American Journal of Kidney Diseases 2005, 3

[10]

Capox方案联合阿司匹林治疗老年转移性结肠癌的临床观察 [J].

左新年 ;

丁江华 ;

邹国辉 .

中华临床医师杂志(电子版), 2013, 7 (06) :2397-2400

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