RhoA/ROCK信号通路对血管平滑肌收缩的调节作用及研究进展

被引：25

作者：

张婷

周江睿

王云霞

蒋春雷

机构：

[1] 第二军医大学军事航海医学教研室

来源：

现代生物医学进展 | 2010年 / 10卷 / 12期

关键词：

RhoA; ROCK; 平滑肌收缩; MLCP; MLC磷酸化;

D O I：

10.13241/j.cnki.pmb.2010.12.021

中图分类号：

R331.32 [];

学科分类号：

摘要：

血管平滑肌的异常收缩是引起许多疾病的重要因素,如高血压,脑血管痉挛等,对于平滑肌收缩调节机制的研究为治疗这些疾病带来新的思路和方向。研究表明小GTP结合蛋白RhoA及其下游信号分子ROCK在平滑肌收缩调节,尤其是钙敏化调节机制中起到关键作用。RhoA/ROCK通路通过抑制MLCP活性而增强MLC的磷酸化水平,从而调节平滑肌收缩,此外,它还参与调节其它细胞的多种细胞功能,如应力纤维的生成,细胞分裂及迁移等。本综述主要介绍RhoA/ROCK通路在血管平滑肌收缩功能的调节机制及研究进展。

引用

页码：2367 / 2370

页数：4

共 10 条

[1]

一种新的平滑肌调控蛋白Calponin.[J].唐大椿，向继洲，鲁文彤.生物化学与生物物理进展.1996, 04

[2]

ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells [J].

Wang, Yuepeng ;

Zheng, Xiaoyu Rayne ;

Riddick, Nadeene ;

Bryden, Meredith ;

Baur, Wendy ;

Zhang, Xin ;

Surks, Howard K. .

CIRCULATION RESEARCH, 2009, 104 (04) :531-U226

[3]

Smooth muscle cell calcium activation mechanisms [J].

Berridge, Michael J. .

JOURNAL OF PHYSIOLOGY-LONDON, 2008, 586 (21) :5047-5061

[4]

Mechanisms of rho kinase regulation of vascular reactivity following hemorrhagic shock in rats [J].

Li, Tao ;

Liu, Liangming ;

Liu, Jiancang ;

Ming, Jia ;

Xu, Jing ;

Yang, Guangming ;

Zhang, Yuan .

SHOCK, 2008, 29 (01) :65-70

[5]

Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats [J].

Hilgers, Rob H. P. ;

Todd, Joseph, Jr. ;

Webb, R. Clinton .

JOURNAL OF HYPERTENSION, 2007, 25 (08) :1687-1697

[6]

Ca2+ dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle [J].

Dimopoulos, George J. ;

Semba, Shingo ;

Kitazawa, Kazuyo ;

Eto, Masumi ;

Kitazawa, Toshio .

CIRCULATION RESEARCH, 2007, 100 (01) :121-129

[7]

The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice [J].

Williams, Janae ;

Bogwu, Justin ;

Oyekan, Adebayo .

JOURNAL OF HYPERTENSION, 2006, 24 (07) :1429-1436

[8]

A role for Rho kinase in vascular contraction evoked by sodium fluoride [J].

Jeon, SB ;

Jin, FX ;

Kim, JI ;

Kim, SH ;

Suk, K ;

Chae, SC ;

Jun, JE ;

Park, WH ;

Kim, IK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 343 (01) :27-33

[9]

Rho kinases in cardiovascular physiology and pathophysiology [J].

Loirand, G ;

Guérin, P ;

Pacaud, P .

CIRCULATION RESEARCH, 2006, 98 (03) :322-334

[10]

The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction..[J].Karl Swärd;Mitsuo Mita;David P. Wilson;Jing Ti Deng;Marija Susnjar;Michael P. Walsh.Current hypertension reports.2002, 1

← 1 →