运动训练对大鼠局灶性脑梗死区周边皮质GFAP、GAP-43表达的影响

被引：8

作者：

邓小鹿 ^{[1
]}

刘发益 ^{[1
]}

胡德文 ^{[2
]}

黄柏胜 ^{[1
]}

贺芳 ^{[1
]}

杨丽娟 ^{[1
]}

刘亚东 ^{[2
]}

王玉成 ^{[2
]}

邬力祥 ^{[1
]}

机构：

[1] 中南大学湘雅医学院生理学系

[2] 国防科技大学机电工程与自动化学院自动控制系

来源：

现代生物医学进展 | 2008年 / 06期

关键词：

星形胶质细胞; 脑梗死; 运动; 突触;

D O I：

10.13241/j.cnki.pmb.2008.06.061

中图分类号：

R87 [运动医学]; R743.33 [脑栓塞];

学科分类号：

100216 ;

摘要：

目的:观察运动训练对大鼠局灶性脑梗死区周围皮质的胶质纤维酸性蛋白(glial fibrillary acidic protein,GFAP)和生长相关蛋白-43(growth-associated protein,GAP-43)表达的影响。方法:成年健康雄性SD大鼠42只,随机分为3组:运动组,静止组,假手术对照组。运动组造模后给予电动跑台训练,每天30min;静止组造模后置于普通笼中饲养,不予康复训练;假手术对照组仅给予麻醉及头皮切开、缝合。采用光化学方法建立局灶性脑梗死模型,每组大鼠于术后7d,14d,21d处死,应用免疫组化方法观察各组大鼠不同时期梗死灶周围皮质GFAP和GAP-43的表达.结果:运动组梗死灶周围皮质GFAP的表达在14d和21d显著高于静止组和假手术对照组。运动组大鼠GAP-43表达在7d为最高,14d后开始下降,但均显著高于静止组和假手术对照组。静止组大鼠GAP-43表达在7d和14d高于假手术对照组。21d时三组大鼠GAP-43表达无明显差异。结论:运动训练能促进梗死灶周围皮质GFAP和GAP-43的表达,促进脑缺血后的突触发生与重建。

引用

页码：1009 / 1010+1015+2 +1015

页数：4

共 10 条

[1] S-100 protein and neu- ron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute isehemic stroke. Missler U,Wiesmann M,Friedrich C,et al. Stroke . 1998
[2] Persistent Defect in Transmitter Release and Synapsin Phosphorylation in Cerebral Cortex after Transient Moderate Ischemic Injury. Bolay H,Yasemin G,Sara Y,et al. Stroke . 2002
[3] Molecular mechanisms controlling cortical gliogenesis. Sauvageot CM,Stiles CD. Current Opinion in Neurobiology . 2002
[4] Molecular mechanisms controlling cortical gliogenesis
Sauvageot, CM
Stiles, CD
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2002, 12 (03) : 244 - 249
[5] Neuroprotection associated with running: is it a result of increased endogenous neurotrophic factors?[J] . E.T Ang,P.T.H Wong,S Moochhala,Y.K Ng. &nbspNeuroscience . 2003 (2)
[6] Neuroprotection associated with running:is it a result of increased endogenous neurotrophic fac- tors. Ang ET,Wong PT,Moochhala S,et al. Neuroscience . 2003
[7] Growth-associated protein 43 is up-regulated in the ganglion cells of the ischemic rat retina. Ju WK,Gwon JS,Park SJ,et al. Neu- roreport . 2002
[8] New roles for astrocytes:regulation of CNS synaptogenesis. Slezak M,Pfrieger FW. Trends in Neurosciences . 2003
[9] Effects of rehabilitation training on the expression of S-100,GFAP and Nestin in the cortex of rats with cerebral infarction. Yuan Hua,Long Hua,Li Ling. Chinese Journal of Physical Medicine and Re- habilitation . 2003
[10] Glial changes following an excito- toxic lesion in the CNS.Ⅱ.Astrocytes.. Dusart I,Marry S,PeschanskiM. Neuroscience . 1991

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