肠易激综合征患者结肠粘膜细胞超微结构的研究

被引:9
作者
虞功清
郑筱雯
邹伟民
赵莉
祝金泉
余扬帆
机构
[1] 江西省医学科学研究所电镜室
[2] 江西医学院消化系病研究所
[3] 南昌大学生命学院电镜室 江西南昌
[4] 江西南昌
关键词
肠易激综合症; 结肠粘膜; 扫描电镜;
D O I
暂无
中图分类号
R574.4 [肠道功能紊乱];
学科分类号
1002 ; 100201 ;
摘要
用电子显微镜观察6例肠易激综合症(IBS)患者,2例慢性结肠炎和2例正常对象结肠粘膜超微结构。结果显示,IBS患者结肠粘膜上皮细胞膜完整,细胞形态无异常,细胞间隙紧密,细胞微绒毛分布不规整,密度低而不均,长短方向不一,但线粒体、粗面内质网等细胞器无规律性和明显的变化。而IBS患者粘膜上皮中杯状细胞、浆细胞、肥大细胞和神经内分泌细胞内均可查见大量的分泌颗粒、空泡和粗面内质网等,呈现功能活跃和分泌旺盛状态。提示:IBS结肠粘膜内肥大细胞、浆细胞、神经内分泌细胞和杯状细胞的超微结构改变可能与IBS发病机制相关。
引用
收藏
页码:529 / 532
页数:4
相关论文
共 7 条
[1]  
Bladder mast cell expression of high affinity oestrogen reception in patients with interstitial cystitis. Pang X,Cotreau-Bibbo MM,Sant G R,et al. British Journal of Urology . 1995
[2]  
Irritable bowel syndromea technical review for practice quideline development. Drossman D A,Whitead W E,Camilleri M. Gastroenterology . 1997
[3]  
Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells. Castagliuolo L,Lamont J T,Qiu B,et al. American Journal of Physiology . 1996
[4]  
Boosted systemic immune and local responsiveness after intestinal inflammation in orally sensitized guinea pigs. Fargeas M J,Theodorou V,More J,et al. Gastroenterology . 1995
[5]  
Epidemiology of colonic symptoms and the irritable bowel syndrome. Talley N J,Zinsmoiister A R,Van Dyke C,et al. Gastroenterology . 1991
[6]  
Mast cells: a possible link between psychological stress, enteric infection, food allergy and gut hypersensitivity in the irritable bowel syndrome. Gui X Y. Journal of Gastroenterology . 1998
[7]  
Inereased mast cells in the irritable bowel syndrome. Osullivan M,Claydon N,Breslin N P,et al. Neurngastroenterol Motil . 2000