吗啡抑制呼吸与脑中乙酰胆碱含量间的关系

被引:4
作者
葛晓群
许程鹏
卞春甫
机构
[1] 徐州医学院神经药理研究室
关键词
吗啡; 纳洛酮; 呼吸; 乙酰胆碱; 放射免疫测定法;
D O I
暂无
中图分类号
学科分类号
摘要
本文在观察兔呼吸的同时,用放射免疫法测定延髓和脑桥Ach含量。iv吗啡4.0mg/kg,呼吸频率减慢,延髓和脑桥Ach含量下降,呼吸频率及Ach含量一时间曲线有很好的对应关系。iv吗啡2.0—8.0mg/kg,呼吸频率和Ach含量均呈剂量依赖性下降,两者有正相关。icv纳洛酮0.2mg/kg,能拮抗脑桥但不能拮抗延髓Ach含量下降作用。结果表明吗啡抑制呼吸与低位脑干Ach含量下降有关。
引用
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页码:83 / 86
页数:4
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