人参皂苷Rg2对SHR大鼠血压及肾脏MMP2、MMP9表达的影响

被引：26

作者：

李超民

罗薇

李慧

彭利静

刘薇

拓步雄

机构：

[1] 中国人民解放军第医院心内科

来源：

心脏杂志 | 2017年 / 29卷 / 01期

关键词：

人参皂苷; 高血压; 肾脏; 基质金属蛋白酶; 表达;

D O I：

10.13191/j.chj.2017.0012

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的研究人参皂苷Rg2对自发性高血压大鼠(SHR)血压的影响及肾脏组织中基质金属蛋白酶(MMP)2和MMP9表达的影响。方法采用无创大鼠鼠尾测压仪测量各组大鼠动脉血压及心率,Realtime PCR检测大鼠肾脏组织MMP2、MMP9的mRNA水平,Western Blot检测MMP2、MMP9的蛋白水平。结果与WKY大鼠相比,SHR大鼠的体质量、肾脏质量、心率均无明显变化,血压包括收缩压、舒张压及平均动脉压均显著性增高(P<0.05)。Rg2处理4周后,SHR大鼠的血压均显著性降低(P<0.05),WKY大鼠的血压无明显变化。SHR大鼠的MMP2和MMP9的mRNA水平均明显高于WKY大鼠(P<0.05)。Rg2处理4周后,SHR大鼠的MMP2和MMP9的mRNA水平均显著下降(P<0.05),WKY大鼠的MMP2和MMP9的mRNA水平无明显变化。Rg2处理后SHR大鼠的MMP2和MMP9蛋白变化趋势与mRNA变化趋势一致。结论 Rg2显著降低SHR大鼠的血压以及肾脏组织MMP2和MMP9的表达。

引用

页码：44 / 47

页数：4

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