基于他克林的多靶点乙酰胆碱酯酶抑制剂的研究进展

被引：5

作者：

叶敏忠 ^{[1
]}

成志毅 ^{[2
]}

皮荣标 ^{[1
]}

机构：

[1] 广州中山大学药学院药理毒理实验室

[2] 广州中山大学药物化学实验室

来源：

中国药理学通报 | 2008年 / 12期

关键词：

他克林; 乙酰胆碱酯酶; 多靶点; 阿尔采末病;

D O I：

暂无

中图分类号：

R971 [神经系统药物];

学科分类号：

1007 ;

摘要：

乙酰胆碱酯酶(acetylcholinesterase,AChE)是目前治疗阿尔采末病(Alzheimer’s disease,AD)的一个重要靶点。其中基于他克林的二联体(dimeric)和杂合体(hybrid)的研究得到广泛重视。设计思路正由同时结合AChE双位点提高抑制活性和选择性转变为针对AD多靶点定向作用的开发。该文综述了基于他克林的二联体或杂合体的抗AD研究进展及对其展望。

引用

页码：1549 / 1554

页数：6

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