白细胞介素-18及其抗肿瘤作用研究进展

被引：1

作者：

杜开南

赵永尧

张松林

机构：

[1] 三峡大学第一临床医学院胸心外科

来源：

现代生物医学进展 | 2007年 / 03期

关键词：

白细胞介素-18; 肿瘤; 树突状细胞;

D O I：

10.13241/j.cnki.pmb.2007.03.046

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 ;

摘要：

白细胞介素18(IL-18)具有多向免疫调节功能。它对T细胞向Th1或Th2分化起有独特的调节能力。最近的研究表明了IL-18的结构、活化形式和调节树突状细胞、NK细胞等方面的重要功能。研究也发现许多肿瘤患者血清IL-18水平显著升高及其在肿瘤发生发展中的作用。本文主要介绍了IL-18的结构、产生与调节、生物学作用及其在肿瘤方面的研究进展。

引用

页码：458 / 459

页数：2

共 19 条

[1] Effective induction of therapeutic antitumor immunity by dendritic cells coexpressing interleukin-18 and tumor antigen [J].

Xia, DJ ;

Zheng, S ;

Zhang, WP ;

He, L ;

Wang, QQ ;

Pan, JP ;

Zhang, LH ;

Wang, J ;

Cao, XT .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2003, 81 (09) :585-596

[2]

Memory CD8+T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen. BERG R,CROSSLEY E,MURRAY S,et al. Annual Review of Immunology . 2003

[3] Impact of serum interleukin-18 level as a prognostic indicator in patients with epithelial ovarian carcinoma [J].

Akahira J.-I. ;

Konno R. ;

Ito K. ;

Okamura K. ;

Yaegashi N. .

International Journal of Clinical Oncology, 2004, 9 (1) :42-46

[4]

Study on interleukin-18 gene transfer into human breast cancer cells to prevent tumorigenicity[J] . Ming-yong Han,Shu Zheng,Jin-ming Yu,Jia-ping Peng,Qi-sen Guo,Jia-lin Wang. &nbspJournal of Zhejiang University Science . 2004 (4)

[5]

Nonredundant roles for CD1 drestricted natual killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to IL-18 treatment of mice. YOSHIMOTO T,MIZUTANI H,SUGIMOTO T,et al. Life Sciences . 2003

[6]

Serum levels of interleukin-18 and sICAM-1 in patients affected by breast cancer: preliminary considerations. MERENDINO RA,Gangemi S,Arena A,et al. International Journal of Biological Markers . 2001

[7]

Serum levels of interleukin-18 and soluble interleukin-2 receptor (sIL-2R) in lung cancer. NAUMNIK J,AMEIC K. Roczniki Akademii Medycznej w Bialymstoku . 2004

[8]

Cloning of a new cytkine that induces IFN-gamma production by T cells. OKAMURA H,TSUTSI H,KOMATSU T,et al. Nature . 1995

[9]

Interleukin-18 inhibits osteolytic bone metasis by human lung cancer cells possibly through suppression of osteoclastic bone-resorption in nude mice. IWASAKIT,Yamashita K,Tsujimura T,et al. Journal of Immunotherapy . 2002

[10]

Serum interleukin-18 and nitric oxide activity in bladder carcinoma. BUKAN N,SOZEN S,COSKUN U,et al. Eue Cytokine Neyw . 2003

← 1 2 →