腹腔镜与开腹结直肠癌根治术对机体免疫系统影响的Meta分析

被引：4

作者：

吴泽生

刘兵

高华

张文斌

机构：

[1] 新疆医科大学第一附属医院胃肠外科

来源：

新疆医科大学学报 | 2014年 / 37卷 / 10期

关键词：

结肠直肠肿瘤; 腹腔镜; 开腹; 免疫; Meta分析;

D O I：

暂无

中图分类号：

R735.34 [];

学科分类号：

摘要：

目的应用Meta分析评价结直肠癌腹腔镜切除术(LS)与开腹手术(OS)对机体免疫系统的影响。方法通过计算机检索Embase、PubMed、Cohorane Library、Web of Science、Medline、万方、知网数据库,收集1991年1月-2013年12月发表的关于结直肠癌腹腔镜切除术与开腹手术术后机体免疫差异的随机对照研究,按照Meta分析的要求对初步检索到的所有研究结果进行质量评估,采用Revman5.1软件对最终入选的研究结果进行分析。结果共纳入10项研究,其中腹腔镜组(LS组)276例,开腹组(OS组)286例。LS组术后T0～1、T1～3时间段血浆中IL-6明显低于OS组(P<0.05),两组术后T3～7时间段差异无统计学意义。LS组术后T1～3时间段血浆中CRP浓度明显低于OS组(P<0.05),两组术后T0～1、T3～7时间段差异无统计学意义(P>0.05)。LS组术后3个时间段(T0～1、T1～3、T3～7)血浆中CD4+均明显高于OS组(P<0.05)。结论 LS组术后部分免疫指标比OS组对人体更有利,但并没有足够的证据说明LS组在术后免疫功能保护上有明显的优越性。

引用

页码：1344 / 1350

页数：7

共 23 条

[1]

Pro-inflammatory Cytokine Release in Rectal Surgery: Comparison Between Laparoscopic and Open Surgical Techniques [J].

Kvarnstrom, Andreas ;

Swartling, Torbjorn ;

Kurlberg, Goran ;

Bengtson, Jan-Peter ;

Bengtsson, Anders .

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2013, 61 (05) :407-411

[2]

Inflammatory and Tumor Stimulating Responses after Laparoscopic Sigmoidectomy [J].

Kim, Jin Soo ;

Hur, Hyuk ;

Min, Byung Soh ;

Lee, Kang Young ;

Chung, Hyun Cheol ;

Kim, Nam Kyu .

YONSEI MEDICAL JOURNAL, 2011, 52 (04) :635-642

[3]

Comparison of immunologic outcomes of laparoscopic vs open approaches in clinical stage III colorectal cancer [J].

Han, Sang-Ah ;

Lee, Woo Yong ;

Park, Chi-Min ;

Yun, Seong Hyeon ;

Chun, Ho-Kyung .

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2010, 25 (05) :631-638

[4]

Systematic review of laparoscopic versus open surgery for colorectal cancer [J].

Reza, M. M. ;

Blasco, J. A. ;

Andradas, E. ;

Cantero, R. ;

Mayol, J. .

BRITISH JOURNAL OF SURGERY, 2006, 93 (08) :921-928

[5]

Immunologic and oncologic implications of laparoscopic surgery: what is the latest?.[J].Lee Sang W;Whelan Richard L.Clinics in colon and rectal surgery.2006, 1

[6]

Prognostic value of vascular endothelial growth factor tumor tissue content of colorectal cancer [J].

Ferroni, P ;

Spila, A ;

Martini, F ;

D'Alessandro, R ;

Mariotti, S ;

Del Monte, G ;

Graziano, P ;

Buonomo, O ;

Guadagni, F ;

Roselli, M .

ONCOLOGY, 2005, 69 (02) :145-153

[7]

Immunological effects of laparoscopic vs open colorectal surgery: a prospective clinical study..[J].Wichmann Matthias W;Hüttl Thomas P;Winter Hauke;Spelsberg Fritz;Angele Martin K;Heiss Markus M;Jauch KarlWalter.Archives of surgery (Chicago; Ill. : 1960).2005, 7

[8]

Lymphocyte subsets and natural killer cell cytotoxicity after laparoscopically assisted resection of rectosigmoid carcinoma [J].

Leung, KL ;

Tsang, KS ;

Ng, MHL ;

Leung, KJ ;

Lai, PBS ;

Lee, JFY ;

Lau, WY .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2003, 17 (08) :1305-1310

[9]

Postoperative cell mediated immune response is better preserved after laparoscopic vs open colorectal resection in humans [J].

Whelan, RL ;

Franklin, M ;

Holubar, SD ;

Donahue, J ;

Fowler, R ;

Munger, C ;

Doorman, J ;

Balli, JE ;

Glass, J ;

Gonzalez, JJ ;

Bessler, M ;

Xie, H ;

Treat, M .

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2003, 17 (06) :972-978

[10]

Systemic and peritoneal inflammatory response after laparoscopic or conventional colon resection in cancer patients - A prospective, randomized trial [J].

Wu, FPK ;

Sietses, C ;

von Blomberg, BME ;

van Leeuwen, PAM ;

Meijer, S ;

Cuesta, MA .

DISEASES OF THE COLON & RECTUM, 2003, 46 (02) :147-155

← 1 2 3 →