Nogo受体——一种潜在的药物研发靶点

被引：4

作者：

严峻

廖红

机构：

[1] 中国药科大学新药筛选中心

来源：

中国药科大学学报 | 2010年 / 41卷 / 04期

关键词：

Nogo受体; 神经损伤与再生; 神经炎症; 脑卒中; 阿尔茨海默症;

D O I：

暂无

中图分类号：

R91 [药物基础科学];

学科分类号：

1007 ;

摘要：

Nogo受体(NgR)作为髓鞘相关抑制分子受体,在中枢神经损伤和再生抑制过程中起关键作用。近年来,包括其轴突生长抑制、细胞移动调节等众多功能的发现,使Nogo受体的研究受到了神经医学界和药学界更为广泛的重视。本文综述了NgR复合物的组成和在神经损伤和再生过程中的功能,重点探讨了NgR在某些疾病发生和发展的过程中的作用,以及以NgR为药物开发靶点的潜在应用,为将来以NgR为靶点的药物开发和相关疾病的临床治疗提供有益的参考。

引用

收藏

页码：306 / 311

页数：6

相关论文

共 21 条

[1]

Patterns of Nogo-A, NgR, and RhoA expression in the brain tissues of rats with focal cerebral infarction[J] . Wen Jiang,Feng Xia,Junliang Han,Jincun Wang.Translational Research . 2009 (1)

[2] Myelin regulates immune cell adhesion and motility [J].

Pool, Madeline ;

Niino, Masaaki ;

Rambaldi, Isabel ;

Robson, Kristin ;

Bar-Or, Amit ;

Fournier, Alyson E. .

EXPERIMENTAL NEUROLOGY, 2009, 217 (02) :371-377

[3] Nogo-A expression after focal ischemic stroke in the adult rat [J].

Cheatwood, Joseph L. ;

Emerick, April J. ;

Schwab, Martin E. ;

Kartje, Gwendolyn L. .

STROKE, 2008, 39 (07) :2091-2098

[4] Immunization with recombinant Nogo-66 receptor (NgR) promotes axonal regeneration and recovery of function after spinal cord injury in rats [J].

Yu, Panpan ;

Huang, Lidong ;

Zou, Jian ;

Yu, Zhihua ;

Wang, Yanxia ;

Wang, Xiaofei ;

Xu, Liang ;

Liu, Xinqiu ;

Xu, Xiao-Ming ;

Lu, Pei-Hua .

NEUROBIOLOGY OF DISEASE, 2008, 32 (03) :535-542

[5] Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis [J].

Wang, Qiang ;

Gou, Xingchun ;

Xiong, Lize ;

Jin, Weilin ;

Chen, Shaoyang ;

Hou, Lichao ;

Xu, Lixian .

ANESTHESIOLOGY, 2008, 108 (06) :1071-1080

[6] A role for Nogo receptor in macrophage clearance from injured peripheral nerve [J].

Fry, Elizabeth J. ;

Ho, Carole ;

David, Samuel .

NEURON, 2007, 53 (05) :649-662

[7] TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions [J].

Satoh, J. ;

Tabunoki, H. ;

Yamamura, T. ;

Arima, K. ;

Konno, H. .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2007, 33 (01) :99-107

[8] Time-dependent increase in Nogo-A expression after focal cerebral ischemia in marmoset monkeys [J].

Eslamboli, Andisheh ;

Grundy, Robert I. ;

Irving, Elaine A. .

NEUROSCIENCE LETTERS, 2006, 408 (02) :89-93

[9] Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease [J].

Simard, AR ;

Soulet, D ;

Gowing, G ;

Julien, JP ;

Rivest, S .

NEURON, 2006, 49 (04) :489-502

[10] Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury [J].

Li, SX ;

Kim, JE ;

Budel, S ;

Hampton, TG ;

Strittmatter, SM .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2005, 29 (01) :26-39