氟西汀对大鼠海马脑源性神经营养因子基因表达的作用

被引:5
作者
许珂
张永亮
郁缪宇
刘协和
机构
[1] 华西医科大学附一院心理卫生研究所!广州市精神病医院成都
[2] 华西医科大学法医学系!成都
[3] 华西医科大学附一院心理卫生研究所
关键词
氟西汀; 脑源性神经营养因子; 大鼠; 海马; 原位杂交;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
目的 为了进一步探讨抗抑郁药作用的分子机制。方法 采用原位杂交技术 (地高辛标记的BDNFcDNA探针 )检测长期给予抗抑郁药氟西汀及生理盐水大鼠海马神经元BDNFmRNA的表达。结果 与生理盐水组相比 ,氟西汀组表达增强 ,尤以CA3、CA1区为甚。结论 长期给药后脑内有关区域BDNF表达改变可能是抗抑郁效应发生的受体后分子作用机制之一
引用
收藏
页码:453 / 455
页数:3
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