伴焦虑症状的抑郁症患者认知功能研究

被引：29

作者：

何小婷 ^{[1
,2
]}

孙宁 ^{[1
]}

杜巧荣 ^{[1
]}

李素萍 ^{[1
]}

徐勇 ^{[1
]}

左丽娜 ^{[1
]}

张玉欣 ^{[1
]}

张克让 ^{[1
]}

机构：

[1] 太原, 山西医科大学第一医院精神卫生科

[2] 太原, 山西医科大学医学心理学教研室

来源：

中华行为医学与脑科学杂志 | 2016年 / 25卷 / 05期

关键词：

抑郁症; 焦虑症状; 认知功能;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100204 [神经病学];

摘要：

目的探讨伴焦虑症状的抑郁症患者认知功能的特点及其影响因素。方法对458名首发抑郁症患者使用汉密尔顿焦虑量表(HAMA)评定焦虑程度, 根据量表得分划分为无焦虑症状组(n=76)和伴焦虑症状组(n=266), 并使用威斯康星卡片分类测验(WCST)、Stroop色-词关联测验、可重复性成套神经心理状态测验(RBANS)评定其认知功能。结果 (1)无焦虑症状组在完成分类数、学习到学会、即刻记忆、视觉广度、注意、延时记忆上的得分[分别为(2.88±2.14)分, (64.16±24.20)分, (81.78±17.16)分, (84.08±15.41)分, (106.45±20.72)分, (86.12±13.06)分]高于伴焦虑症状组[分别为(2.07±1.98)分, (54.33±27.05)分, (70.47±17.61)分, (79.76±14.63)分, ( 98.25±17.11)分, (79.97±16.10)分], 差异有统计学意义(P<0.01或P<0.05);无焦虑症状组在在错误应答数、持续错误百分比、单色时间、字义干扰时、颜色干扰时上的得分[分别为(61.21±21.50)分, (17.11±6.10)分, (19.04±6.57)分, (15.01±9.11)分, (2.79±2.82)分]低于伴焦虑症状组[分别为(67.20±21.87)分, (19.21±7.18)分, (21.03±7.69)分, (17.92±10.64)分, (3.86±5.61)分], 差异有统计学意义(P<0.05)。(2)受教育年限、年龄、躯体性焦虑、精神性焦虑共同解释了即刻记忆28.1%的变异量(F=25.015, P<0.01);受教育年限和精神性焦虑共同解释了延时记忆19.8%的变异量(F=31.625, P<0.01);年龄和精神性焦虑共同解释了字义干扰时13.6%的变异量(F=20.293, P<0.01)。结论伴焦虑症状的抑郁症在执行功能、认知加工速度、记忆及注意上的损伤比无焦虑症状的抑郁症更为严重, 受教育年限、年龄、精神性焦虑及躯体性焦虑是其影响因素。

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