应激易化成瘾及复吸的生物学机制

被引：10

作者：

张瑞岭

李凌江

郝伟

机构：

[1] 湖南医科大学附二院精研所!长沙,,湖南医科大学附二院精研所!长沙,,湖南医科大学附二院精研所!长沙,

来源：

中国临床心理学杂志 | 2000年 / 01期

关键词：

Addiction; Neurobiology;

D O I：

10.16128/j.cnki.1005-3611.2000.01.023

中图分类号：

R996 [有机毒物];

学科分类号：

100405 ;

摘要：

In this review, the possible neurobiological mechanisms of stress in drug addiction and relapse are discussed. Curent evidence suggests that, the adrenal hormones, glucocortiocoids, which increase the sensitivity of mesencephalic dopaminergic neurons to drugs, seem to be one of the biological substrates of the effects of stress on the propensity to develop drug intake. Stress can induce relapse, at least in part, by activating the mesolimbic dopamine system via several paths and subsequently stimulating D2 -dopamine receptors which mediate the appetitive phase of drug reinforcement.

引用

页码：64 / 67

页数：4