依达拉奉对于急性脑梗死溶栓患者MMP-9水平及出血性转化的影响

被引：16

作者：

陈春燕

孙晓江

陆学胜

机构：

[1] 上海交通大学附属第六人民医院神经内科

来源：

中国老年学杂志 | 2015年 / 35卷 / 13期

关键词：

依达拉奉; 重组组织型纤溶酶原激活物; 基质金属蛋白酶-9; 出血性转化;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

<正>重组组织型纤溶酶原激活物(rt-PA)是美国食品和药品监督管理局(FDA)唯一批准使用于急性缺血性卒中溶栓治疗的药物,时间窗内rt-PA静脉溶栓为目前公认的改善缺血性卒中结局最有效的治疗方法,有效改善血管再通及神经功能损伤〔1〕。NINDS〔2〕、亚特兰蒂斯(ALTLANTIS)以及欧洲协作急性卒中研究(ECASS)等临床研究结果都证明了卒中3 h内使用rt-PA静脉溶栓安全有效〔3〕,ECASSⅢ用13年研究把时间窗扩

引用

页码：3788 / 3791

页数：4

共 28 条

[1]

A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood–brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion[J] . Nobukazu Miyamoto,Loc-Duyen D. Pham,Takakuni Maki,Anna C. Liang,Ken Arai.Neuroscience Letters . 2014

[2]

Effects of edaravone on early outcomes in acute ischemic stroke patients treated with recombinant tissue plasminogen activator[J] . Tomoki Wada,Hideo Yasunaga,Ryota Inokuchi,Hiromasa Horiguchi,Kiyohide Fushimi,Takehiro Matsubara,Susumu Nakajima,Naoki Yahagi.Journal of the Neurological Sciences . 2014 (1-2)

[3]

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke[J] . Mayank Chaturvedi,Leszek Kaczmarek.Molecular Neurobiology . 2014 (1)

[4]

Intravenous Thrombolysis with Neuroprotective Therapy by Edaravone for Ischemic Stroke Patients Older than 80 Years of Age[J] . Syoichiro Kono,Kentaro Deguchi,Nobutoshi Morimoto,Tomoko Kurata,Toru Yamashita,Yoshio Ikeda,Hisashi Narai,Yasuhiro Manabe,Yoshiki Takao,Sanami Kawada,Kenichi Kashihara,Yasushi Takehisa,Satoshi Inoue,Hideki Kiriyama,Koji Abe.Journal of Stroke and Cerebrovascular Diseases . 2013

[5] MMP9 Variation After Thrombolysis Is Associated With Hemorrhagic Transformation of Lesion and Death [J].

Inzitari, Domenico ;

Giusti, Betti ;

Nencini, Patrizia ;

Gori, Anna Maria ;

Nesi, Mascia ;

Palumbo, Vanessa ;

Piccardi, Benedetta ;

Armillis, Alessandra ;

Pracucci, Giovanni ;

Bono, Giorgio ;

Bovi, Paolo ;

Consoli, Domenico ;

Guidotti, Mario ;

Nucera, Antonia ;

Massaro, Francesca ;

Micieli, Giuseppe ;

Orlandi, Giovanni ;

Perini, Francesco ;

Tassi, Rossana ;

Tola, Maria Rosaria ;

Sessa, Maria ;

Toni, Danilo ;

Abbate, Rosanna .

STROKE, 2013, 44 (10) :2901-2903

[6]

Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat[J] . Ajmal Ahmad,Mohd. Moshahid Khan,Hayate Javed,Syed Raza,Tauheed Ishrat,M. Badruzzaman Khan,Mohammed Safhi,Fakhrul Islam.Molecular and Cellular Biochemistry . 2012 (1)

[7]

Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice[J] . Phil Lee,Jieun Kim,Rachel Williams,Rajat Sandhir,Eugene Gregory,William M. Brooks,Nancy E.J. Berman.Experimental Neurology . 2011 (1)

[8]

Matrix metalloproteinase 9 mRNA: An early prognostic marker for patients with acute stroke[J] . Colin A. Graham,Rebecca W.Y. Chan,Dexter Y.S. Chan,Cangel P.Y. Chan,Lawrence K.S. Wong,Timothy H. Rainer.Clinical Biochemistry . 2011 (4-5)

[9]

Effects of Edaravone, a Free Radical Scavenger, on Serum Levels of Inflammatory Biomarkers in Acute Brain Infarction[J] . Kenji Isahaya,Koji Yamada,Masato Yamatoku,Kenzo Sakurai,Satoshi Takaishi,Bunta Kato,Toshikazu Hirayama,Yasuhiro Hasegawa.Journal of Stroke and Cerebrovascular Diseases . 2012 (2)

[10]

Matrix Metalloproteinase-9 as a Marker for Acute Ischemic Stroke: A Systematic Review[J] . Maria Ramos-Fernandez,M. Fernanda Bellolio,Latha G. Stead.Journal of Stroke and Cerebrovascular Diseases . 2011 (1)

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