β-纤维蛋白原基因-455G/A多态性与脑梗死的关系

被引：4

作者：

张晨

机构：

[1] 青岛大学医学院附属医院神经内科山东青岛

来源：

青岛大学医学院学报 | 2003年 / 04期

关键词：

脑梗死; 纤维蛋白原; 基因型; 基因频率; 等位基因;

D O I：

暂无

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

①目的　研究 β 纤维蛋白原基因启动子区域 - 4 5 5G/A基因变异与血浆纤维蛋白原水平及脑梗死的相关性。②方法　随机抽取住院高血压脑梗死病人 86例 (脑梗死组 ) ,高血压非脑梗死病人 85例 (高血压组 ) ,门诊健康查体者 90例 (对照组 ) ,用多聚酶链反应加HaeⅢ内切酶检测 β 纤维蛋白原基因启动子区域 - 4 5 5G/A的多态性。③结果　脑梗死组A-455等位基因的分布频率明显高于高血压组及对照组 (χ2 =7.0 1、4 .4 0 ,P <0 .0 1、0 .0 5 )。④结论　血浆中纤维蛋白原水平受 β 纤维蛋白原基因 - 4 5 5G/A多态性的影响 ,A-455等位基因是脑梗死的一个相对独立的危险因素。

引用

页码：367 / 369

页数：3

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