氯沙坦对充血性心衰患者血循环中肿瘤坏死因子和白介素-6的干预

被引：5

作者：

杨兵生

王声愿

蒋文平

机构：

[1] 苏州大学附属第一医院心内科

来源：

国外医学心血管疾病分册. | 2001年 / 01期

关键词：

充血性心力衰竭; 肿瘤坏死因子; 白介素-6; 氯沙坦;

D O I：

暂无

中图分类号：

R541.6 [血液循环衰竭];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨氯沙坦对充血性心力衰竭患者血循环中炎性细胞因子:肿瘤坏死因子(TNF-α)和白介素6(IL-6)浓度的影响。方法:将47例心衰患者随机分为氯沙坦组(n=24)给予氯沙坦25～50mg/d和苯那普利组(n=23)给予苯那普利5～10mg/d治疗4周,治疗前后分别抽血6ml,用ELISA法检测TNF-α、IL-6浓度。同时抽检10例健康志愿者作为对照组。结果:(1)心衰患者中TNF-α、IL-6浓度较正常对照组显著升高(P<0.05),并与心功能级别呈正相关。氯沙坦治疗4周后能使TNF-α、IL-6浓度显著降低(P<0.05)。(2)苯那普利组TNF-α、IL-6浓度亦显著降低,但氯沙坦组降低IL-6较苯那普利组显著(P<0.05)。结论:氯沙坦治疗心衰4周后能显著降低病人血清中TNF-α。IL-6浓度。

引用

页码：43 / 45

页数：3

共 6 条

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