Dickkopf-1在强直性脊柱炎病理过程中作用研究进展

被引：5

作者：

雷鹏真

危国军

裴孝鹏

康凯

董大明

机构：

[1] 哈尔滨医科大学附属第二医院骨三科

来源：

中华实用诊断与治疗杂志 | 2012年 / 26卷 / 12期

基金：

黑龙江省自然科学基金;

关键词：

强直性脊柱炎; Wnt信号传导通路; Dkk-1; 骨生成;

D O I：

暂无

中图分类号：

R593.23 [强直性脊柱炎];

学科分类号：

100201 [内科学];

摘要：

Dickkopf-1(Dkk-1)是Wnt信号路径的天然抑制因子,通过抑制Wnt信号传导通路影响骨化活动。体内Dkk-1血清水平降低、与Dkk-1受体的黏附功能下降或Dkk-1功能受损均可降低Dkk-1对Wnt信号传导通路的抑制作用,促进细胞内β-连环蛋白水平升高并活化,从而调节成骨细胞分化和倾向于骨生成,最终使强直性脊柱炎患者形成关节强直。强直性脊柱炎的炎症本身不受Dkk-1影响,且可以诱导Dkk-1的表达。

引用

页码：1149 / 1151

页数：3

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