实验性抑郁症大鼠缰核和海马BDNF基因表达

被引:13
作者
夏薇
赵华
任爱华
沈维高
机构
[1] 吉林大学基础医学院生理教研室
关键词
抑郁症; 缰核; 海马; BDNF基因;
D O I
暂无
中图分类号
R749.4 [情感性精神病];
学科分类号
摘要
目的:研究抑郁症大鼠缰核和海马BDNF基因的表达情况。方法:采用长期未预知应激刺激致大鼠抑郁症模型,运用open field和forcedswimmingtest法观察大鼠行为学变化。运用免疫组化法检测缰核和海马BDNF基因的表达。结果:与正常对照组相比,抑郁症模型组大鼠海马和缰核均表现为BDNF阳性细胞数量明显减少。结论:实验性抑郁症大鼠缰核、海马BDNF基因表达水平降低。
引用
收藏
页码:277 / 278
页数:2
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