水通道蛋白-依赖性细胞迁移的研究进展

被引:22
作者
缪睿
李昌煜
机构
[1] 浙江中医药大学
关键词
水通道蛋白; 细胞迁移; 血管生成; 星形胶质细胞; 肿瘤转移; 板状伪足;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100103 [病原生物学];
摘要
水通道蛋白(AQPs)是一类介导跨膜水运输的内在蛋白。近年来,一些研究成果证实,AQP具有介导细胞迁移的功能。该文综述了各种不同类型的AQPs-依赖性细胞迁移(AQPs-dependent cell migration):AQP1促进内皮细胞迁移;AQP4促进星形胶质细胞迁移;AQP3促进角膜上皮细胞、肠上皮细胞、皮肤角质形成细胞的迁移。此外,AQPs还能促进肿瘤细胞的迁移,增加肿瘤细胞的转移潜能。AQPs介导的细胞迁移与许多疾病有着内在联系,调控AQP的表达是一种尚待开发的治疗手段。
引用
收藏
页码:601 / 605
页数:5
相关论文
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