巨噬细胞在炎症性肠病中作用的研究进展

被引：23

作者：

王跃 ^{[1
]}

王志斌 ^{[2
]}

李玲 ^{[2
]}

张立超 ^{[1
]}

机构：

[1] 上海中医药大学附属市中医医院

[2] 第二军医大学药学院药理教研室

来源：

国际消化病杂志 | 2016年 / 36卷 / 01期

关键词：

炎症性肠病; 克罗恩病; 溃疡性结肠炎; 巨噬细胞; 炎性介质;

D O I：

暂无

中图分类号：

R574 [肠疾病];

学科分类号：

100201 [内科学];

摘要：

炎症性肠病(IBD)是一种病因不明的慢性非特异性肠道炎性疾病,由巨噬细胞介导的炎性反应在IBD的发展过程中起着关键作用。研究发现,在IBD患者的肠道炎性反应中,巨噬细胞的数量明显增加,并且可释放白细胞介素-1(IL-1)、IL-6、IL-18、转化生长因子-β(TGF-β)和肿瘤坏死因子-α(TNF-α)等多种生物活性物质,在IBD的发生发展中起重要作用。因此,了解巨噬细胞释放的细胞因子和化学介质在IBD中的关键作用,可以为治疗IBD开拓新的方法。

引用

页码：18 / 21

页数：4

共 14 条

[1]

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation [J].

Dou, Wei ;

Zhang, Jingjing ;

Ren, Gaiyan ;

Ding, Lili ;

Sun, Aning ;

Deng, Chao ;

Wu, Xiaojun ;

Wei, Xiaohui ;

Mani, Sridhar ;

Wang, Zhengtao .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2014, 23 (01) :170-178

[2]

Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells [J].

Andujar, I. ;

Rios, J. L. ;

Giner, R. M. ;

Recio, M. C. .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 49 (04) :637-641

[3]

The cell biology of the intestinal epithelium and its relation to inflammatory bowel disease [J].

Deuring, J. Jasper ;

de Haar, Colin ;

Kuipers, Ernst J. ;

Peppelenbosch, Maikel P. ;

van der Woude, C. Janneke .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2013, 45 (04) :798-806

[4]

High Levels of Proinflammatory Cytokines; but Not Markers of Tissue Injury; in Unaffected Intestinal Areas from Patients with IBD.[J].Alberto J. León;Emma Gómez;Jose A. Garrote;David Bernardo;Asterio Barrera;Jose L. Marcos;Luis Fernández-Salazar;Benito Velayos;Alfredo Blanco-Quirós;Eduardo Arranz;Donna-Marie McCafferty.Mediators of Inflammation.2009,

[5]

Biological Therapies for Inflammatory Bowel Diseases [J].

Rutgeerts, Paul ;

Vermeire, Severine ;

Van Assche, Gert .

GASTROENTEROLOGY, 2009, 136 (04) :1182-1197

[6]

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients [J].

Szkaradkiewicz, Andrzej ;

Marciniak, Ryszard ;

Chudzicka-Strugala, Izabela ;

Wasilewska, Agnieszka ;

Drews, Micha ;

Majewski, Przemyslaw ;

Karpinski, Tomasz ;

Zwozdziak, Barbara .

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2009, 57 (04) :291-294

[7]

Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis [J].

Olsen, Trine ;

Goll, Rasmus ;

Cui, Guanglin ;

Husebekk, Anne ;

Vonen, Barthold ;

Birketvedt, Grethe Stoa ;

Florholmen, Jon .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2007, 42 (11) :1312-1320

[8]

Modulating TNF-α signaling with natural products.[J].Atish T. Paul;Vikrantsinh M. Gohil;Kamlesh K. Bhutani.Drug Discovery Today.2006, 15

[9]

Inhibition of Smad7 With a Specific Antisense Oligonucleotide Facilitates TGF-β1–Mediated Suppression of Colitis.[J].Monica Boirivant;Francesco Pallone;Claudia Di Giacinto;Daniele Fina;Ivan Monteleone;Mariarosaria Marinaro;Roberta Caruso;Alfredo Colantoni;Giampiero Palmieri;Massimo Sanchez;Warren Strober;Thomas T. MacDonald;Giovanni Monteleone.Gastroenterology.2006, 6

[10]

Quantitative measurement of cytokine mRNA in inflammatory bowel disease:: relation to clinical and endoscopic activity and outcome [J].

Raddatz, D ;

Bockemühl, M ;

Ramadori, G .

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2005, 17 (05) :547-557

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