扇贝多肽对60Coγ射线诱导的胸腺细胞凋亡的影响

被引：4

作者：

梁军

关印

宋玉华

姚如永

机构：

[1] 青岛大学医学院附属医院肿瘤治疗研究中心

来源：

中华放射医学与防护杂志 | 2004年 / 03期

关键词：

扇贝多肽; 辐射防护剂; 凋亡; γ射线;

D O I：

暂无

中图分类号：

R817 [放射性同位素在医学上的应用];

学科分类号：

1001 ; 100105 ; 100207 ; 100602 ;

摘要：

目的　评价扇贝多肽对6 0 Coγ射线诱导的胸腺细胞凋亡的作用。方法　昆明小鼠胸腺细胞6 0 Coγ射线 3Gy照射 ,吸收剂量率 0 6Gy/min。实验分空白对照组 ,模型组 ,扇贝多肽不同浓度 ( 0 5 ,0 2 5和 0 12 5mg/ml)预处理为实验组 ,通过受照细胞形态、生化、DNA和相关酶变化来进行评价。结果　经扇贝多肽预处理的实验组细胞有较低的细胞毒性 ,细胞凋亡受到抑制 ,细胞脂质过氧化 (MDA)水平有所降低而超氧化物歧化酶 (SOD)活性可以维持在正常水平。结论　扇贝多肽对6 0Coγ射线照射所致昆明小鼠胸腺细胞的损伤有保护作用

引用

页码：63 / 65

页数：3

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