万古霉素肾毒性的研究进展

被引：57

作者：

胡佳丽 ^{[1
,2
]}

张菁 ^{[1
,2
]}

机构：

[1] 复旦大学附属华山医院抗生素研究所

[2] 卫生部抗生素临床药理重点实验室

来源：

中国感染与化疗杂志 | 2013年 / 13卷 / 05期

关键词：

万古霉素; 肾毒性; 影响因素; 给药方案;

D O I：

10.16718/j.1009-7708.2013.05.019

中图分类号：

R96 [药理学];

学科分类号：

100706 [药理学];

摘要：

<正>自1958年问世以来,万古霉素作为治疗耐甲氧西林金葡菌(MRSA)最常用的糖肽类抗生素已经应用了50余年。近年来,随着MRSA检出率的上升,万古霉素被作为治疗MRSA检出的首选药物广泛使用。在关注该药疗效的同时,对其不良反应的防治也越来越不容忽视,而该药主要的不良反应是肾毒性[1]。万古霉素的肾毒性反应最初主要是所含杂质太

引用

页码：394 / 399

页数：6

共 19 条

[1]

Mitochondrial superoxide production contributes to vancomycin-induced renal tubular cell apoptosis [J].

Arimura, Yohei ;

Yano, Takahisa ;

Hirano, Megumi ;

Sakamoto, Yuya ;

Egashira, Nobuaki ;

Oishi, Ryozo .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 52 (09) :1865-1873

[2]

Biopsy-Proven Acute Tubular Necrosis Associated with Vancomycin in an Adult Patient [J].

Belen, Cary ;

Budhiraja, Pooja ;

Bracamonte, Erika ;

Popovtzer, Mordecai .

RENAL FAILURE, 2012, 34 (04) :502-505

[3]

Ceftaroline Fosamil: A Cephalosporin With Activity Against Methicillin-Resistant Staphylococcus Aureus [J].

Poon, Henry ;

Chang, Mei H. ;

Fung, Horatio B. .

CLINICAL THERAPEUTICS, 2012, 34 (04) :743-765

[4]

Protective role of curcumin in nephrotoxic oxidative damage induced by vancomycin in rats.[J].Mohamed H.S. Ahmida.Experimental and Toxicologic Pathology.2010, 3

[5]

Elevated vancomycin trough is not associated with nephrotoxicity among inpatient veterans [J].

Prabaker, Kavitha K. ;

Tran, Thuong P. -H. ;

Pratummas, Tamara ;

Goetz, Matthew Bidwell ;

Graber, Christopher J. .

JOURNAL OF HOSPITAL MEDICINE, 2012, 7 (02) :91-97

[6]

Retrospective evaluation of possible renal toxicity associated with continuous infusion of vancomycin in critically ill patients.[J].Herbert Spapen;Karin Janssen van Doorn;Marc Diltoer;Walter Verbrugghe;Rita Jacobs;Nadia Dobbeleir;Patrick Honoré;Philippe Jorens.Annals of Intensive Care.2011, 1

[7]

Incidence and Risk Factors Influencing the Development of Vancomycin Nephrotoxicity in Children [J].

McKamy, Susan ;

Hernandez, Elvin ;

Jahng, Maximillian ;

Moriwaki, Tiffany ;

Deveikis, Audra ;

Le, Jennifer .

JOURNAL OF PEDIATRICS, 2011, 158 (03) :422-426

[8]

Vancomycin-associated nephrotoxicity: a critical appraisal of risk with high-dose therapy.[J].Annie Wong-Beringer;Julianne Joo;Edmund Tse;Paul Beringer.International Journal of Antimicrobial Agents.2010, 2

[9]

Increasing Vancomycin Serum Trough Concentrations and Incidence of Nephrotoxicity [J].