阿尔茨海默病的发病机制和细胞周期假说

被引:16
作者
李晓晴
王力
冯立群
王薇
机构
[1] 北京市安贞医院神经内科
关键词
阿尔茨海默病; 细胞周期; 发病机制;
D O I
暂无
中图分类号
R749.16 [];
学科分类号
摘要
<正>AD是1906年由德国医师Alois Alzheimer最先描述,并以他的名字而命名的。他首先报道了1例55岁的女性患者,该患者在生前遭受严重的包括记忆、语言和社交能力在内的认知功能障碍的折磨。Alzheimer在其大脑标本中发现了一些特殊结构并对其进行了描述,这就是我们现在熟知的老年
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[1]
Localizations of endogenous APP/APP-proteolytic products are consistent with microtubular transport [J].
Zitnik, Galynn ;
Wang, Lin ;
Martin, George M. ;
Hu, Qubai .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2007, 31 (01) :59-68
[2]
Sequential expression of cell‐cycle regulators and Alzheimer's disease–related proteins in entorhinal cortex after hippocampal excitotoxic damage.[J].KarinaHernández‐Ortega;PatriciaFerrera;ClorindaArias.J. Neurosci. Res..2007, 8
[3]
Alzheimer's disease: the two-hit hypothesis [J].
Zhu, XW ;
Raina, AK ;
Perry, G ;
Smith, MA .
LANCET NEUROLOGY, 2004, 3 (04) :219-226
[4]
Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the ‘Dr. Jekyll and Mr. Hyde concept’ of Alzheimer’s disease or the yin and yang of neuroplasticity.[J].Thomas Arendt.Progress in Neurobiology.2003, 2
[5]
Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons [J].
Gärtner, U ;
Brückner, MK ;
Krug, S ;
Schmetsdorf, S ;
Staufenbiel, M ;
Arendt, T .
ACTA NEUROPATHOLOGICA, 2003, 106 (06) :535-544
[6]
Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's Disease neuropathology [J].
Xiang, ZM ;
Ho, L ;
Valdellon, J ;
Borchelt, D ;
Kelley, K ;
Spielman, L ;
Aisen, PS ;
Pasinetti, GM .
NEUROBIOLOGY OF AGING, 2002, 23 (03) :327-334
[7]
Constitutive Cdc25B tyrosine phosphatase activity in adult brain neurons with M phase-type alterations in Alzheimer's disease [J].
Vincent, I ;
Bu, B ;
Hudson, K ;
Husseman, J ;
Nochlin, D ;
Jin, LW .
NEUROSCIENCE, 2001, 105 (03) :639-650
[8]
Activation of cell cycle-associated proteins in neuronal death: a mandatory or dispensable path? [J].
Copani, A ;
Uberti, D ;
Sortino, MA ;
Bruno, V ;
Nicoletti, F ;
Memo, M .
TRENDS IN NEUROSCIENCES, 2001, 24 (01) :25-31
[9]
Abortive apoptosis in Alzheimer's disease.[J].Arun K. Raina;Ayala Hochman;Xiongwei Zhu;Catherine A. Rottkamp;Akihiko Nunomura;Sandra L. Siedlak;Heather Boux;Rudolph J. Castellani;George Perry;Mark A. Smith.Acta Neuropathologica.2001, 4
[10]
Familial Alzheimer's disease presenilin-1 mutants potentiate cell cycle arrest [J].
Janicki, SM ;
Stabler, SM ;
Monteiro, MJ .
NEUROBIOLOGY OF AGING, 2000, 21 (06) :829-836