ERK信号转导通路与类风湿关节炎

被引：15

作者：

王建竹

孔祥英

林娜

机构：

[1] 中国中医科学院中药研究所

来源：

中国病理生理杂志 | 2011年 / 27卷 / 02期

基金：

北京市自然科学基金;

关键词：

细胞外信号调节激酶类; 关节炎,类风湿;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

100201 [内科学];

摘要：

<正>丝裂原活化蛋白激酶(mitogen-activated proteinkinases,MAPKs)信号转导通路是细胞外信号引起细胞核内反应的重要通路,而细胞外信号调节激酶(extracellular signal-regulated kinase,ERK)通路是MAPKs家族中的重要成员,其异常活化与类风湿关节炎(rheumatoid arthritis,RA)关节破坏的病理过程密切相关。

引用

收藏

页码：398 / 402

页数：5

相关论文

共 6 条

[1]

FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice [J].

Ohori, Makoto ;

Takeuchi, Mikio ;

Maruki, Riyo ;

Nakajima, Hidenori ;

Miyake, Hiroshi .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2007, 374 (04) :311-316

[2]

New therapeutics that treat rheumatoid arthritis by blocking T-cell activation.[J].Neill M. MacKenzie.Drug Discovery Today.2006, 19

[3]

Endothelial extracellular matrix - Biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization [J].

Davis, GE ;

Senger, DR .

CIRCULATION RESEARCH, 2005, 97 (11) :1093-1107

[4]

TNF-α modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-κB signalling pathway [J].

Scott, BB ;

Zaratin, PF ;

Gilmartin, AG ;

Hansbury, MJ ;

Colombo, A ;

Belpasso, C ;

Winkler, JD ;

Jackson, JR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 328 (02) :409-414

[5]

The ERK cascade.[J].Hadara Rubinfeld;Rony Seger.Molecular Biotechnology.2005, 2

[6]

Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes [J].

Liacini, A ;

Sylvester, J ;

Li, WQ ;

Huang, WS ;

Dehnade, F ;

Ahmad, M ;

Zafarullah, M .

EXPERIMENTAL CELL RESEARCH, 2003, 288 (01) :208-217