mTOR通路及其抑制剂抗肿瘤的研究进展

被引：44

作者：

黄嘉佳

林桐榆

机构：

[1] 华南肿瘤学国家重点实验室

来源：

癌症 | 2007年 / 12期

关键词：

哺乳动物雷帕霉素靶蛋白; 肿瘤; 靶向治疗;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学];

学科分类号：

100214 [肿瘤学];

摘要：

哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是PI3K/Akt通路的下游分子,可接受生长因子、营养、能量等多种信号,是细胞生长和增殖的关键调节分子。许多肿瘤中存在有编码mTOR信号通路相关蛋白的基因突变,这些蛋白的异常表达可引起mTOR通路的过度激活。目前,以mTOR为治疗靶点成为肿瘤治疗的研究新热点。本文就近年来有关mTOR通路及其抑制剂在抗肿瘤方面的研究进展作一综述。

引用

页码：1397 / 1403

页数：7

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