Keap1-Nrf2/ARE信号通路的抗氧化应激作用及其调控机制

被引：128

作者：

胡流芳

王迎

任汝静

霍海如

孙建辉

李洪梅

朱亚英

谭余庆

机构：

[1] 中国中医科学院中药研究所中药安全评价中心

来源：

国际药学研究杂志 | 2016年 / 43卷 / 01期

关键词：

Kelch样环氧氯丙烷相关蛋白-1; 核因子E2相关因子2; 抗氧化反应元件; 氧化应激; 调控机制;

D O I：

10.13220/j.cnki.jipr.2016.01.022

中图分类号：

R363 [病理生理学];

学科分类号：

摘要：

Kelch样环氧氯丙烷相关蛋白-1(Keap1)-核因子E2相关因子2(Nrf2)/抗氧化反应元件(ARE)信号通路是细胞氧化应激反应中的关键通路,其调控的下游Ⅱ相代谢酶和抗氧化蛋白/酶在细胞防御保护中发挥重要作用,也是近几年抗氧化研究领域的热点。本文从基本结构(包括Nrf2、Keap1及ARE三者的结构)、抗氧化应激作用(包括Keap1-Nrf2/ARE信号通路的基本功能及其信号通路调控的下游靶蛋白)、调控机制(包括Nrf2与Keap1的解偶联、Nrf2的降解减弱机制、门闩和枢纽学说及其他机制)等3方面就Keap1-Nrf2/ARE信号通路的抗氧化应激作用及其调控机制进行综述。

引用

页码：146 / 152+166 +166

页数：8

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