大肠埃希氏菌产超广谱β-内酰胺酶研究进展

被引:12
作者
杨佰侠
机构
[1] 安徽医科大学附一院检验科合肥
关键词
大肠埃希氏菌; β-内酰胺酶; 耐药性;
D O I
10.13461/j.cnki.wna.003926
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
大肠埃希氏菌产 β -内酰胺酶是其对 β -内酰胺类抗生素耐药的主要机制 ,所产 β -内酰胺酶种类繁多、特性各异。并在 β -内酰胺类抗生素广泛应用的选择压力下 ,不断有新的 β -内酰胺酶产生。本文对大肠埃希氏菌产 β -内酰胺酶 (ESBL ,IRTs ,AmpC)的耐药机制的研究进展作简要综述。
引用
收藏
页码:64 / 70
页数:7
相关论文
共 27 条
[1]  
MolecularcharacterizationoftheOXA -7β-lactamasegene. ScoulicaE,AransayA,TselentisY. Antimicrobial Agents and Chemotherapy . 1995
[2]  
AcomplexmutantofTem-1β-lactamasewithmutationsencounteredinbothIRT -4andextended-spectrumTEM -15,producedbyanEs cherichiacoliclinicalisolate. SirotD,ReculeE,ChaibiB ,etal. AntimicrobAgentsChemoth er . 1997
[3]  
Molecular basis of AmpC hyperproduction in clinical isolates of Escherichia coli. Nelson EC,Elisha BG. Antimicrobial Agents and Chemotherapy . 1999
[4]  
-11 mutation in the ampC promoter increasing resistance to beta-Lactams in a Clinical Escherichia coli Strain. Corvec S,Caroff N,Espaze E,et al. Antimicrobial Agents and Chemotherapy . 2002
[5]  
Nucleotide sequence and characterization of a novel cefotaxime-hydrolyzing β-Lactamase(CTX-M-10) isolatedin Spain. Olivor A,Perez-dfaz JC,Coque TM,et al. Antimicrobial Agents and Chemotherapy . 2001
[6]  
Cloning and sequence of the gene encoding a novel cefotaxime-hydrolyzing β-lactamase(CTX-M-9) from Escherichia coli in Spain. Sabate M,Tarrago R,Navarro F,et al. Antimicrobial Agents and Chemotherapy . 2000
[7]  
CTX-M-14, a Plasmid-mediated CTX-M type extended-spectrum β-lactamase Isolated from Escherichia coli. Ia L,Ishii Y,Chang FY,et al. Antimicrobial Agents and Chemotherapy . 2002
[8]  
Inhibitor-resistant TEM β-lactamases:phenotypic, genetic and biochemical characteristics. Chaibi EB,Sirot D,Paul G,et al. Antimicrobial Agents and Chemotherapy . 1999
[9]  
A functional classification scheme for β-lactamases and its correlation with molecular structure. Bush K,Jacoby GA,Medeiros AA. Antimicrobial Agents and Chemotherapy . 1995
[10]  
Sequences of the NPS-1 and TLE-1 β-lactamase genes. Pai H,Jacoby GA. Antimicrobial Agents and Chemotherapy . 2001