乏氧诱导因子促进肿瘤侵袭转移的研究进展

被引：5

作者：

董兰兰

袁响林

机构：

[1] 华中科技大学同济医学院附属同济医院肿瘤科

来源：

中国肿瘤生物治疗杂志 | 2006年 / 05期

关键词：

乏氧诱导因子; 转移; 黏附分子;

D O I：

暂无

中图分类号：

R730.2 [肿瘤病理学、病因学];

学科分类号：

100214 ;

摘要：

肿瘤细胞在乏氧环境中会发生一系列生物学行为的改变,包括肿瘤侵袭性和转移能力的增加,其中乏氧诱导因子-1α(hypoxiainduciactor1α,HIF-1α)起关键作用。HIF-1α可作用于多个环节促进肿瘤转移。在细胞运动方面肝细胞生长因子(HGF)的受体c-Met在乏氧时增加,能促进细胞活动性并通过与肝细胞生长因子结合而增加细胞的侵袭性;基质降解方面肿瘤细胞侵袭转移能力与其产生或诱导MMPs的能力密切相关,HIF-1可引起MMPs的表达增加,进而促进恶性肿瘤的转移;细胞黏附方面HIF-1α可通过对肿瘤细胞黏附分子表达的影响而促进肿瘤转移;血管生成方面乏氧能引起VEGF表达的上调,在肿瘤发生早期向血管生成型转变过程中,HIF-1α介导了VEGF的上调;细胞凋亡方面HIF-1上调凋亡抑制因子Bcl-2,抑制凋亡,从而增强肿瘤转移力。HIF-1α亦可上调凋亡抑制因子p21,从而抑制凋亡使肿瘤恶性程度增加易于转移。对HIF-1α的研究可能是治疗肿瘤、减少恶性肿瘤转移的一种新途径。

引用

页码：390 / 392

页数：3

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