软骨下骨在骨关节炎发病机制中的研究进展

被引：12

作者：

汪听亚

裘敏蕾

樊天佑

机构：

[1] 上海中医药大学附属市中医医院

来源：

中国骨与关节杂志 | 2016年 / 5卷 / 02期

关键词：

骨关节炎; 软骨关节; 软骨; 膝关节;

D O I：

暂无

中图分类号：

R684.3 [关节炎];

学科分类号：

100220 [骨科学];

摘要：

<正>骨关节炎(osteoarthritis,OA)是一种慢性关节疾病,临床研究及流行病学研究表明,骨关节炎的风险因素众多,包括年龄、负重改变及外伤等。然而,其发病机制仍然不明确。目前研究显示,软骨下骨和软骨板存在许多结构改变,如钙化软骨层增厚,双重潮线,软骨下骨硬化,骨囊肿,骨髓病损和骨赘形成等[1]。软骨下骨的重要性得到了公认,软骨下骨的变化与关节疾病发展存在相关性,并且可能在疾病进展机制中起重要作用[2-3]。

引用

页码：149 / 153

页数：5

共 36 条

[1]

Intermittent applied mechanical loading induces subchondral bone thickening that may be intensified locally by contiguous articular cartilage lesions [J].

Poulet, B. ;

de Souza, R. ;

Kent, A. V. ;

Saxon, L. ;

Barker, O. ;

Wilson, A. ;

Chang, Y. -M. ;

Cake, M. ;

Pitsillides, A. A. .

OSTEOARTHRITIS AND CARTILAGE, 2015, 23 (06) :940-948

[2]

Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats.[J].Zhuang Cui;Changpeng Xu;Xue Li;Jinqi Song;Bin Yu.Bone.2015,

[3]

MRI signal-based quantification of subchondral bone at the tibial plateau: a population study [J].

MacKay, James W. ;

Godley, Keith C. ;

Toms, Andoni P. .

SKELETAL RADIOLOGY, 2014, 43 (11) :1567-1575

[4]

The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis.[J].A. Sin;W. Tang;C.Y. Wen;S.K. Chung;K.Y. Chiu.Osteoarthritis and Cartilage.2014,

[5]

Three-dimensional analysis of subchondral cysts in hip osteoarthritis: An ex vivo HR-pQCT study.[J].Ko Chiba;Andrew J. Burghardt;Makoto Osaki;Sharmila Majumdar.Bone.2014,

[6]

Correlation of subchondral bone morphometry and OARSI grade in osteoarthritic human knee samples.[J].M. Finnilä;O-M. Aho;V. Tiitu;J. Thevenot;J. Rautiainen;M. Nieminen;M. Valkealahti;P. Lehenkari;S. Saarakkala.Osteoarthritis and Cartilage.2014,

[7]

Targeting TGFβ signaling in subchondral bone and articular cartilage homeostasis [J].

Zhen, Gehua ;

Cao, Xu .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2014, 35 (05) :227-236

[8]

The effects of defect size, orientation, and location on subchondral bone contact in oval-shaped experimental articular cartilage defects in a bovine knee model [J].

Flanigan, David C. ;

Harris, Joshua D. ;

Brockmeier, Peter M. ;

Lathrop, Rebecca L. ;

Siston, Robert A. .

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2014, 22 (01) :174-180

[9]

Reviewing subchondral cartilage surgery: considerations for standardised and outcome predictable cartilage remodelling [J].

Benthien, Jan P. ;

Behrens, Peter .

INTERNATIONAL ORTHOPAEDICS, 2013, 37 (11) :2139-2145

[10]

Shock absorbing ability of articular cartilage and subchondral bone under impact compression.[J].Fatemeh Malekipour;Chris Whitton;Denny Oetomo;Peter Vee Sin Lee.Journal of the Mechanical Behavior of Biomedical Materials.2013,

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