心力衰竭部分药物治疗的循证医学新进展

被引:17
作者
黄俊玲
罗明
机构
[1] 同济大学附属同济医院心血管内科
关键词
心力衰竭; 循证医学; B型利钠肽; 左西孟旦; 托伐普坦; 他汀类药物; 阿利吉仑;
D O I
暂无
中图分类号
R541.6 [血液循环衰竭]; R-03 [];
学科分类号
100201 [内科学];
摘要
近年来,对慢性心力衰竭的治疗研究不断进步,一些新的药物临床试验给治疗带来希望:重组B型利钠肽可以改善患者的临床症状,提高生活质量,不影响肾功能,但对长期预后无良性影响;左西孟旦对慢性心力衰竭急性加重者可改善血流动力学参数,缓解临床症状,但对长期生存率的改善无明显证据;托伐普坦能改善患者的临床症状,对肾功能无不良影响,但长期生存率和死亡率无明显改善;他汀类药物从理论上讲应该可以改善患者的长期生存率和死亡率,但目前的临床证据尚无法统一结论;阿利吉仑可能会对患者的长期病死率产生良性影响,改善预后。该文从这5种药物的循证医学方面就慢性心力衰竭药物治疗的最新研究进展简要综述。
引用
收藏
页码:30 / 33
页数:4
相关论文
共 11 条
[1]
Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors.[J].Suzanne Oparil;E Pimenta.Therapeutics and Clinical Risk Management.2009, defa
[2]
Statin Therapy and Clinical Outcomes in Heart Failure: A Propensity-Matched Analysis [J].
Ouzounian, Maral ;
Tu, Jack V. ;
Austin, Peter C. ;
Chong, Alice ;
Liu, Peter P. ;
Lee, Douglas S. .
JOURNAL OF CARDIAC FAILURE, 2009, 15 (03) :241-248
[3]
Atorvastatin might improve ventricular electrostability and decelerate the deterioration of renal function in patients with heart failure and diabetes mellitus [J].
Kishi, Takuya ;
Yamada, Akira ;
Okamatsu, Shuuichi ;
Sunagawa, Kenji .
JOURNAL OF CARDIOLOGY, 2009, 53 (03) :341-348
[4]
Discrepancy between results of randomized control studies and retrospective analysis.[J].Roman Nevzorov;Victor Novack;Yaakov Henkin;Sergio L. Kobal;Alan Jotkowitz;Avi Porath.European Journal of Internal Medicine.2009, 5
[5]
Randomized Clinical Outcome Trials of Statins in Heart Failure.[J].Gregg C. Fonarow.Heart Failure Clinics.2008, 2
[6]
Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial [J].
Tavazzi, Luigi ;
Maggioni, Aldo P. ;
Marchioli, Roberto ;
Barlera, Simona ;
Franzosi, Maria Grazia ;
Latini, Roberto ;
Lucci, Donata ;
Nicolosi, Gian Luigi ;
Porcu, Maurizio ;
Tognoni, Gianni .
LANCET, 2008, 372 (9645) :1231-1239
[7]
Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy [J].
Ramasubbu, Kumudha ;
Estep, Jerry ;
White, Donna L. ;
Deswal, Anita ;
Mann, Douglas L. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (04) :415-426
[8]
Renin inhibition by aliskiren prevents atherosclerosis progression - Comparison with irbesartan, atenolol, and amlodipine [J].
Nussberger, Juerg ;
Aubert, Jean-Francois ;
Bouzourene, Karima ;
Pellegrin, Maxime ;
Hayoz, Daniel ;
Mazzolai, Lucia .
HYPERTENSION, 2008, 51 (05) :1306-1311
[9]
The Second Follow-up Serial Infusions of Nesiritide (FUSION II) trial for advanced heart failure: Study rationale and design [J].
Yancy, Clyde W. ;
Krum, Henry ;
Massie, Barry M. ;
Silver, Marc A. ;
Stevenson, Lynne Warner ;
Cheng, Mei ;
Kim, Sun Sook ;
Evans, Rosemary .
AMERICAN HEART JOURNAL, 2007, 153 (04) :478-484
[10]
伴有低钠血症的心力衰竭的治疗进展 [J].
黄震华 .
中国新药与临床杂志, 2008, (05) :384-387