以锇的分子氢配合物作1HNMR探针研究抗癌金属化合物与脱氧鸟苷酸的配位作用

被引:4
作者
杨频
郭茂林
李青山
田燕妮
LiZaiwei
HenryTaube
机构
[1] 山西大学分子科学研究所!太原
[2] 南京大学配位化学国家重点实验室
[3] 南京大学配位化学国家重点实
关键词
锇分子氢配合物; lHNMR探针; 抗癌金属化合物; 脱氧鸟苷酸;
D O I
暂无
中图分类号
O641.4 [络合物化学(配位化学)];
学科分类号
070304 ; 081704 ;
摘要
锇的分子氢配合物[trans-en2Os(η-H2)]2+(en,乙二胺)是一种新的生物分子1H NMR识别探针.本文首次以该探针研究了抗癌金属化合物二氯二茂钛、二氯二乙基锡、二乙基邻菲咯啉二氯合锡及顺铂与脱氧鸟苷酸(dGMP)在接近生理条件下重水溶液中的配位作用.结果表明,前三者主要与dGMP的磷酸氧发生强的配位作用,而顺铂主要与dGMP的碱基N(7)发生配位作用.
引用
收藏
页码:304 / 310
页数:7
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