与P-糖蛋白及MDR1基因关联的药物转运研究现状

被引：23

作者：

冯慧玲

熊玉卿

机构：

[1] 南昌大学临床药理研究所/江西省临床药物代谢动力学重点实验室

来源：

中国临床药理学杂志 | 2014年 / 30卷 / 11期

关键词：

P-糖蛋白; 药代动力学; MDR1基因; 核因子κB; 孕烷X受体;

D O I：

10.13699/j.cnki.1001-6821.2014.11.027

中图分类号：

R969.1 [药物代谢动力学];

学科分类号：

100710 [药物代谢动力学];

摘要：

P-糖蛋白(P-gp)由MDR1基因编码,腺苷三磷酸依赖的药物外向转运蛋白,是介导药物吸收与转运动力学的关键转运体。不少药物通过核因子κB(NF-κB)和孕烷X受体(PXR)信号通路直接影响MDR1基因和P-gp的表达,导致P-gp的功能发生改变,从而影响药物的吸收转运。因此,本文对P-gp介导的药物转运相互作用、药物对P-gp和MDR1基因表达的影响,以及与P-gp/MDR1基因表达相关的NF-κB和PXR信号通路的研究概况进行收集与探讨,以期从基因和蛋白水平上,为研究药物吸收转运特征的变化提供一定依据。

引用

页码：1062 / 1064

页数：3

共 12 条

[1]

药物代谢酶和转运蛋白介导的灯盏花素药物相互作用研究进展 [J].

高洋洋 ;

赖泳 .

中国医院药学杂志, 2014, 34 (01) :76-79

[2]

Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice [J].

Tian, Qing-E ;

Li, Huan-De ;

Yan, Miao ;

Cai, Hua-Lin ;

Tan, Qin-You ;

Zhang, Wen-Yuan .

WORLD JOURNAL OF GASTROENTEROLOGY, 2012, 18 (47) :7079-7086

[3]

Caco-2细胞单层模型中熊果酸摄取转运机制的研究 [J].

程晓华 ;

熊玉卿 .

中草药, 2009, (12) :1935-1939

[4]

Drug-Drug Interaction Studies of Cardiovascular Drugs Involving P-Glycoprotein, an Efflux Transporter, on the Pharmacokinetics of Edoxaban, an Oral Factor Xa Inhibitor [J].

Mendell, Jeanne ;

Zahir, Hamim ;

Matsushima, Nobuko ;

Noveck, Robert ;

Lee, Frank ;

Chen, Shuquan ;

Zhang, George ;

Shi, Minggao .

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2013, 13 (05) :331-342

[5]

Effects of nifedipine on the pharmacokinetics of repaglinide in rats: Possible role of CYP3A4 and P-glycoprotein inhibition by nifedipine [J].

Choi, Jin-Seok ;

Choi, In ;

Choi, Dong-Hyun .

PHARMACOLOGICAL REPORTS, 2013, 65 (05) :1422-1430

[6]

P-glycoprotein is responsible for the poor intestinal absorption and low toxicity of oral aconitine: In vitro, in situ, in vivo and in silico studies [J].

Yang, Cuiping ;

Zhang, Tianhong ;

Li, Zheng ;

Xu, Liang ;

Liu, Fei ;

Ruan, Jinxiu ;

Liu, Keliang ;

Zhang, Zhenqing .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 273 (03) :561-568

[7]

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.[J].Juan Pablo Rigalli;María Laura Ruiz;Virginia Gabriela Perdomo;Silvina Stella Maris Villanueva;Aldo Domingo Mottino;Viviana Alicia Catania.Toxicology.2011, 1

[8]

Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation [J].

Kim, Hyung Gyun ;

Tran Thi Hien ;

Han, Eun Hee ;

Hwang, Yong Pil ;

Choi, Jae Ho ;

Kang, Keon Wook ;

Kwon, Kwang-il ;

Kim, Bong-Hee ;

Kim, Sang Kyum ;

Song, Gye Yong ;

Jeong, Tae Cheon ;

Jeong, Hye Gwang .

BRITISH JOURNAL OF PHARMACOLOGY, 2011, 162 (05) :1096-1108

[9]

Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.[J].Bu Tong Sun;Li Hua Zheng;Yong Li Bao;Chun Lei Yu;Yin Wu;Xiang Ying Meng;Yu Xin Li.European Journal of Pharmacology.2010, 2

[10]

Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line.[J].Carolina I. Ghanem;Agostina Arias;Analia Novak;Griselda Delli Carpini;Silvina Villanueva;Alba G. Blazquez;Jose J.G. Marin;Aldo D. Mottino;Modesto C. Rubio.Biochemical Pharmacology.2010, 2

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