骨关节炎的发病机制及其诊治的研究进展

被引:42
作者
谭静雅
杨南萍
机构
[1] 四川大学华西医院风湿免疫科
关键词
骨关节炎; 发病机制; 诊断标准; 临床治疗;
D O I
暂无
中图分类号
R684.3 [关节炎];
学科分类号
100220 [骨科学];
摘要
面对人口的老龄化趋势及人类寿命的延长,骨关节炎(OA)越来越多见。随着对OA发病机制认识的不断深化,研究工作者们从OA危险因素到病理学改变,从分子生物学改变到免疫学改变,多方面、多角度地研究OA的发病机制。而其临床诊断主要依靠症状体征、影像学和实验室检查相结合,治疗方面在早中晚期可以分别通过保守药物治疗和手术治疗缓解疼痛并改善功能。因此,阐明OA的发病机制,将有利于提高对OA的认识及早期诊断,也是指导OA实验研究及临床治疗的理论依据。
引用
收藏
页码:1828 / 1832
页数:5
相关论文
共 17 条
[1]
T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ [J].
Shen, P. -C. ;
Wu, C. -L. ;
Jou, I. -M. ;
Lee, C. -H. ;
Juan, H. -Y. ;
Lee, P. -J. ;
Chen, S. -H. ;
Hsieh, J. -L. .
OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (06) :728-736
[2]
Temporal expression and tissue distribution of interleukin-1β in two strains of guinea pigs with varying propensity for spontaneous knee osteoarthritis [J].
Santangelo, K. S. ;
Pieczarka, E. M. ;
Nuovo, G. J. ;
Weisbrode, S. E. ;
Bertone, A. L. .
OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (04) :439-448
[3]
Sex hormones and structural changes in osteoarthritis: A systematic review [J].
Tanamas, Stephanie K. ;
Wijethilake, Pushpika ;
Wluka, Anita ;
Davies-Tuck, Miranda L. ;
Urquhart, Donna M. ;
Wang, Yuanyuan ;
Cicuttini, Flavia M. .
MATURITAS, 2011, 69 (02) :141-156
[4]
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis.[J].Xin Li;Gary Gibson;Jae-Sung Kim;Jeffrey Kroin;Shunbin Xu;Andre J. van Wijnen;Hee-Jeong Im.Gene.2011, 1
[5]
Relationships between measures of muscular performance, proprioceptive acuity, and aging in elderly women with knee osteoarthritis [J].
Peixoto, Jennifer Granja ;
Domingues Dias, Joao Marcos ;
Dias, Rosangela Correa ;
da Fonseca, Sergio Teixeira ;
Teixeira-Salmela, Luci Fuscaldi .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2011, 53 (02) :E253-E257
[6]
Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model [J].
Almonte-Becerril, M. ;
Navarro-Garcia, F. ;
Gonzalez-Robles, A. ;
Vega-Lopez, M. A. ;
Lavalle, C. ;
Kouri, J. B. .
APOPTOSIS, 2010, 15 (05) :631-638
[7]
Chondroptosis:: An immunohistochemical study of apoptosis and Golgi complex in chondrocytes from human osteoarthritic cartilage [J].
Pérez, E ;
Luna, J ;
Rojas, L ;
Kouri, JB .
APOPTOSIS, 2005, 10 (05) :1105-1110
[8]
Aging, articular cartilage chondrocyte senescence and osteoarthritis [J].
Martin, JA ;
Buckwalter, JA .
BIOGERONTOLOGY, 2002, 3 (05) :257-264
[9]
盐酸氨基葡萄糖与双氯芬酸钠治疗骨性关节炎疗效对比 [J].
陈作桓 .
吉林医学, 2012, 33 (06) :1230
[10]
兔骨关节炎滑膜组织血管内皮生长因子mRNA表达及透明质酸钠的影响 [J].
周建林 ;
刘世清 ;
邱波 .
中国组织工程研究与临床康复, 2010, 14 (11) :1983-1986