首发未药物治疗青少年重性抑郁障碍患者脑三维结构磁共振病例对照研究

被引:3
作者
丁军 [1 ]
苏林雁 [1 ]
张志强 [2 ]
卢光明 [2 ]
马静 [1 ]
张燕 [1 ]
黄巍 [2 ]
刘晓云 [3 ]
机构
[1] 中南大学湘雅二医院精神卫生研究所
[2] 解放军南京军区总医院医学影像科
[3] 湖南省人民医院放射科
关键词
重性抑郁障碍; 首发; 青少年; 基于体素的形态测量学分析方法(VBM);
D O I
10.16128/j.cnki.1005-3611.2010.04.007
中图分类号
R749.4 [情感性精神病];
学科分类号
100204 [神经病学];
摘要
目的:探讨首发未药物治疗青少年重性抑郁障碍患者脑灰质体积与正常对照组青少年之间的异同。方法:对18名首发未治疗青少年重性抑郁障碍患者和年龄性别匹配的18名青少年健康对照组进行脑三维结构扫描,对脑灰质体积异常变化应用基于体素的形态测量学分析方法VBM进行分析比较。结果:抑郁组相比对照组VBM灰质形态学体积增加的部位主要在右脑颞上回及双侧颞叶颞中回,尤其是BA22和BA19;抑郁组相比对照组VBM体积减少部位主要位于右脑额叶(BA11,47)、左脑顶叶(BA7,40)和右脑顶叶(BA5),左脑岛叶(BA13)及左脑颞叶(BA13)。结论:抑郁组相比对照组的灰质体积以下降为主,主要在右脑额叶及左脑顶叶、右脑顶叶、左脑岛叶和左脑颞叶。
引用
收藏
页码:403 / 406
页数:4
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