DNA免疫诱导的抗轮状病毒抗体反应

被引:3
作者
孙茂盛
GiambiagiS
AfrikanovaIva
StantaG
BurroneO
机构
[1] 中国医学科学院协和医科大学医学生物学研究所!昆明
[2] InternationalCentreforGeneticEngineeringandBiotechnology
[3] Trieste
[4] Italy
[5] DepartmentofPathology
[6] UniversityofTrieste
[7] -Trieste
[8] It
关键词
轮状病毒VP4基因; DNA免疫; 抗体反应;
D O I
10.13200/j.cjb.1998.03.129.sunmsh.001
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
本文报道了用编码轮状病毒SA11毒株VP4蛋白的野生型和经修饰后的基因,以质粒DNA形式免疫动物后,血清抗轮状病毒抗体反应和体内mRNA的表达。用ELISA和微量中和实验分别测定血清中抗轮状病毒抗体,结果表明,所有动物的血清都有不同水平识别轮状病毒抗原成分和中和全病毒的能力。
引用
收藏
页码:129 / 132
页数:4
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