抗结核药物靶点研究最新进展

被引:3
作者
龚立康
肖春玲
机构
[1] 中国医学科学院中国协和医科大学医药生物技术研究所
关键词
抗结核药; 靶点; 结核菌;
D O I
10.13461/j.cnki.wna.004057
中图分类号
R978.3 [抗结核病药、抗麻风病药物];
学科分类号
摘要
近年来结核病又卷土重来,发病率与死亡率明显回升,并且结核菌的耐药问题也日趋严重,成为结核病临床治疗的棘手问题,而在过去的30年里未开发出新型高效的抗结核药物。因此发现潜在的新抗结核药物靶点,研究开发新型抗结核药物,以实现对结核病的有效控制迫在眉睫。文中阐明了抗结核药物与胞壁合成相关的新靶点、与抗耐药有关的新靶点、与核酸稳定性相关的靶点、与电子传递及氧化还原相关的靶点,研究未知作用机制有效物质而发现的新靶点以及与重要代谢途径中关键代谢酶相关的靶点等6个方面研究的新进展,对抗结核新药的研究具有重要指导意义。
引用
收藏
页码:49 / 53+90 +90
页数:6
相关论文
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