运动锻炼促进冠心病血管生成的机制

被引：12

作者：

肖乾凤

郭媛

谭茗月

彭然

赵旺

许丹焰

机构：

[1] 中南大学湘雅二医院心血管内科

来源：

中国动脉硬化杂志 | 2015年 / 09期

关键词：

运动锻炼; 血管生成; 内皮祖细胞; microRNA;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

100201 [内科学];

摘要：

近年来,以运动为核心的心脏康复在预防和治疗心血管疾病上具有重要作用。它能带来诸多心血管益处,越来越多证据支持运动能促进冠心病中血管的生成,但其机制尚未被完全阐明。其中,大量研究证明运动锻炼能增加内皮祖细胞(EPC)的数量及功能,促进血管生成。同时,运动能引起一些microRNA水平的变化,这些microRNA可参与血管生成过程。除此之外,有些microRNA水平的变化可能影响EPC功能而调节血管生成过程。该综述将集中讨论运动锻炼调节EPC和影响microRNA水平促进血管生成的这两条机制,为研究和治疗冠心病提供了新思路。

引用

页码：959 / 964

页数：6

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