内质网应激与疾病

被引：87

作者：

陈娜子

姜潮

李校堃

机构：

[1] 温州医科大学药学院浙江省生物技术与制药工程重点实验室

来源：

中国生物工程杂志 | 2016年 / 36卷 / 01期

关键词：

内质网应激; 未折叠蛋白反应; 疾病; 细胞凋亡;

D O I：

10.13523/j.cb.20160111

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

内质网是蛋白质合成与折叠、维持Ca2+动态平衡及合成脂类和固醇的场所。遗传或环境损伤引起内质网功能紊乱导致内质网应激,激活未折叠蛋白反应。未折叠蛋白反应是一种细胞自我保护性措施,但是内质网应激过强或持续时间过久可引起细胞凋亡。因此,内质网应激与众多人类疾病的发生发展密切相关。最近研究证明,癌症、炎症性疾病、代谢性疾病、骨质疏松症及神经退行性疾病等有内质网应激信号传递参与。然而内质网应激作为一个有效靶点参与各种疾病发挥作用的功能和机制仍然有待进一步研究。在近年来发表的文献基础上对内质网应激与疾病的关系,以及其可能的作用机制进行综述。

引用

页码：76 / 85

页数：10

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